We are thrilled to see the work of Dr. Abhijeet Patil in Cell journal of Cell Reports Medicine reporting modeling of type 1 diabetes using single-cell data cell.com/cell-reports-m… Thanks to our collaborators at The Human Pancreas Analysis Program - HPAP HIRN

Another collaborative effort from the HPAP team! Congratulations Dr. Vahedi!

Patil et al. evaluated the utility of machine learning for early prediction of #type1diabetes using single-cell analysis of islets. cell.com/cell-reports-m…

Congratulations!

Now accepting applications for the Islet Award Initiative (IAI). Supported by JDRF and NIH, will provide up to 100,000 IEQ ($15,000) to investigators who are new to human islet research. iidp.coh.org/Investigators/… NIH NIDDK JDRF Research Dr. Carmella EvansMolina Joyce Niland HIRN #islets

Our latest preprint which is the result of ~8 years of collaboration with the The Human Pancreas Analysis Program - HPAP is now available on bioRxiv. Our work represents the largest existing multiome measurement in pancreatic lymph nodes of humans in health and Type 1 Diabetes: biorxiv.org/content/10.110…

Now accepting applications for the Islet Award Initiative (IAI). Supported by JDRF and NIH, will provide up to 100,000 IEQ ($15,000) to investigators who are new to human islet research. iidp.coh.org/Investigators/… NIH NIDDK JDRF Research Dr. Carmella EvansMolina Joyce Niland HIRN #islets

Research from GregorySchwartz Princess Margaret Cancer Centre Research in collaboration with Penn Medicine have created AnnoSpat, a tool that identifies and maps cell types in tissues. It excels in analyzing complex tissues, like the pancreas. Read more > uhnresearch.ca/news/new-tool-…; doi.org/10.1038/s41467…

Congratulations!

The HIRN Annual Meeting will Jan 13-14, 2025 at NIH Main Campus (Natcher). All interested welcome to attend! Presentations on the state of the diabetes research & future direction of T1D research. #HIRN2025 Register at: niddk.nih.gov/news/meetings-… Please share/retweet!

A review of progress in cell replacement therapies for #T1D #diabetes #stemcells #islets Nature Reviews Endocrinology nature.com/articles/s4157…

The HIRN Annual Meeting will Jan 13-14, 2025 at NIH Main Campus. All interested welcome to attend! Presentations on the state of the diabetes research & future direction of T1D research. #HIRN2025 Register at: niddk.nih.gov/news/meetings-…… Please share/retweet!

The latest HIRN Newsletter is available online! Information about our upcoming meeting, new publications, meetings and funding opportunities! View at: conta.cc/3Xi2D2

AnnoSpat annotates cell types & quantifies cellular arrangements from spatial proteomics ft. Aanchal Mongia, Noah Burget, Yeqiao Zhou 周叶峤, R. Babak Faryabi (Penn Path & Lab Medicine/ Penn Epigenetics), Yue Wang, Klaus H. Kaestner & Golnaz Vahedi (Penn Genetics) & Ali Naji (Penn IDOM) tinyurl.com/3ffj3rey

We welcome investigators to submit their abstracts to present orally or at our poster session during the 17th Annual Scientific Meeting! Deadline is November 18th at 5PM: npod.org/abstracts

Don't wait - register now for the 2025 HIRN Annual Meeting to learn & discuss the state of the diabetes research & future direction of T1D research. Preliminary agenda posted on the website. Register at: niddk.nih.gov/news/meetings-…… All welcome to attend! Please share

Yi and Eizirik re‐analyzed scRNA‐seq data from The Human Pancreas Analysis Program - HPAP database to further investigate the β‐cell stress signatures (e.g, inflammation, autophagy, apoptosis, and ER stress) potentially present in individuals living with #type1diabetes and #type2diabetes. onlinelibrary.wiley.com/doi/10.1111/17…

This Thursday 12/12 come join us for Carmella Evans-Molina Dr. Carmella EvansMolina on ER regulation of beta cell function!

G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells ft. Varun Bahl, Eric Waite Catherine May Elisabetta Manduchi, Benjamin Voight Michelle Lee Mark Tigue, Nicholas Manuto & @KlausKaestner (Penn IDOM/ Penn Genetics) science.org/doi/10.1126/sc…

Looking forward to a great PANC-DB demo at the HIRN meeting!