Our lastest #popgen piece features work of @BryanGitschlag & @theDMMcC (theory), Alej Cano & Joshua L. Payne (data, simulations) Mutation rates (u) matter so, rather than a distribution of fitness effects (DFE), we focus on a joint dist of u and s 1/? biorxiv.org/content/10.110…

Published version of the paper Arlin is referring to at: royalsocietypublishing.org/doi/10.1098/rs…

OBS #Genomics Seminar on #MAVE 📅 Thu, April 11, 10 am ET 🎤 Mseu (IBEC) 📝 An atlas of #amyloid aggregation 🎤 Ammar Tareen (Cold Spring Harbor Laboratory) 📝 MAVE-NN: learning genotype-phenotype maps from MAVE 👉 Register: us02web.zoom.us/meeting/regist… #openscience

I am excited to present my work with David M. McCandlish on our attempt to understand complex genotype-phenotype maps tomorrow at #BoG23. I will show some cool genotype-phenotype maps with up to 16 million genotypes and explain how we can actually visualize and interpret them

✴️Looking for a Research Technician to help me out Adult Infectious Disease Imperial Department of Infectious Disease in London. Let’s explore antibiotic resistance in pathogenic bacteria using deep mutational scanning 🧬🦠🧫 = 🤩 Please share and RT! Deadline 14/06 👇 imperial.ac.uk/jobs/descripti…

Mutation, Randomness and Evolution is coming out in paperback this fall To check if you already have access via your university, visit the web page at OUP using the uni's proxy server All of the figures from the book are available on the OUP web site global.oup.com/academic/produ…

New preprint! Really happy with how this turned out. Hana knocked it out of the park. Colab with Carlos Martí and David M. McCandlish biorxiv.org/cgi/content/sh…

In new study, we develop rigorous method to jointly analyze deep mutational scanning of different protein homologs or conditions We use it to identify mutations w effects on spike-mediated viral entry that differ by >1,000-fold among #SARSCoV2 strains. biorxiv.org/content/10.110…

Reminder: Comp neuro faculty job applications are due Sept 1, 2023 (if you are planning to submit later, please let me know). cshl.edu/about-us/caree… Enjoy the view of Freeman!

CSHL is hiring Faculty at all career stages, in the area of Cancer Biology!Come join me and my amazing colleagues! Application deadline is November 15th. RT and check the link for more info 👇🏼 apply.interfolio.com/129695

I tweeted about this earlier. Fig 2s shows a negative correlation between fitness effect and mut rate @BryanGitschlag David M. McCandlish et al have a theory for how a joint mutation-selection process can induce such correlations. Just came out here: journals.uchicago.edu/doi/10.1086/72…

(1/5) new: A critique of the "isotropic variation" critique The short version is in the first 4 minutes (full version is 40 min) What is the "isotropic variation" critique? What does it get right, or wrong? #popgen #mutation #evolution youtube.com/watch?v=RBALnz…

CSHL’s Zachary Lippman and David M. McCandlish teamed up to decipher the unpredictability of natural and engineered mutations in tomatoes. Their work may help scientists navigate evolution and genome editing. 🍅 cshl.edu/you-say-genome…

Excited to share new work on "Interpreting cis-regulatory mechanisms from genomic deep neural networks using surrogate models” led by Evan Seitz, jointly advised by me and Justin B. Kinney and in collab with David M. McCandlish Paper: biorxiv.org/content/10.110… Docs: squid-nn.readthedocs.io

Special issue of GENETICS on fitness landscapes just announced! Edited by me and Sergey Kryazhimskiy 🇺🇦, submissions due March 18: doi.org/10.1093/geneti…