📢📢📢 Here's our April #NanoBio journal club meeting info! 🗓️ Tues Apr 9, 4pm US Eastern / 1pm US Pacific 🗣️ Luan (Matthew) Nguyen, PhD (The Chan Lab, Biomedical Engineering @ University of Toronto) 📑 nature.com/articles/s4156… 🛰️ tinyurl.com/NanoJCApr2024 Open to all, register above! ☝️🏻☝️🏻☝️🏻 cc: Shrey Sindhwani

Check out our latest perspective in ACS Nano with Natalie Artzi The Chan Lab Twan Lammers Dan Peer Juliane Nguyen Avi Schroeder Anna Schwendeman (she/her) and more on mechanisms and barriers in nanomedicine, based off an amazing Colorado workshop by Dmitri Simberg! pubs.acs.org/doi/full/10.10…

🚨New paper🚨 Ayden and Ayo developed a method to stabilize capture sequences in DNA biosensors. This method improved DNA biosensors' clinical and analytical sensitivity by over 3 and 100-fold. They termed this new strategy RIGID-DNA. Check it out here: tinyurl.com/3t9r5282

Congratulations to Jamie Wu from the The Chan Lab! 🎉 Jamie is the first recipient of the Jennifer Comyn Graduate Award for #Cancer Research. The award supported her research to learn how nanoparticles enter tumours to deliver drugs. #UofT Learn more 👉 uoft.me/2024ComynAward

Meet the editors🧑‍💻 of ACS Nano Part II featuring Grace Han, Luis BioNanoPlasmonicsLab, Tony Hu, Mathieu Mathieu Salanne, Young Hee Lee SKKU, EiC Xiaodong Xiaodong Chen, Chunying Chen National Center For Nanoscience and Technology, and Warren The Chan Lab🙌

Congratulations to our Postdoctoral Alumnus, Dr. Stefan Wilhelm (Stefan Wilhelm) on achieving this significant milestone University of Oklahoma!😃🙌🎊

Congratulations to our new Alumni, Jamie Wu, Ayden Malek, and Matthew Nguyen, on their successful defence! Here is to their next adventure! 🥳🥳

Congratulations to our latest Alumni, Dr. Matthew Osborne, on a successful defence and the creation of the QBox!! 👨‍💻👨‍🎓🥳🎉🥂

We would like to welcome our new Post-doc, Huiyan Li, and PhD student, Daniel Kwon, to Chan Lab!! 🥳🥳

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

🚨New paper🚨 Bringing quantum dot barcodes to the point-of-care! Matt O. et al. designed a portable device that harnesses the unique fluorescence of quantum dots for multiplex diagnostics. Their device runs sample-to-answer in under 40 minutes.⏲️ tinyurl.com/5n97h2f9

🚨New Paper🚨 Stefan Mladjenovic et al. utilized 3D electron microscopy to visualize and study the transport of nanoparticles across tumour blood vessels. Link to paper: tinyurl.com/3usby4dy Below is a thread summarising the method and results:

🚨🚨NEW PAPER ALERT🚨🚨 Jamie Wu et al. discovered the pathways tumour endothelial cells use to transport nanoparticles. Link to paper: rdcu.be/edSeV Below is a thread by Dr. Jamie Wu summarising the method and results:

Here's the latest release from The Chan Lab! 🙌 Jamie Wu and collaborators at Biomedical Engineering @ University of Toronto show that nanoparticles cross tumor #EndothelialCells predominantly using the non-receptor-based macropinocytosis pathway. 💬 More in Nature Nanotechnology | go.nature.com/3FAcZWK

Congratulations to our latest Alumni, Dr. Vanessa Li, on a successful defence!

Congratulations to the academic community at the University of Illinois for a wonderful 20th anniversary event to celebrate the formation of their Department of Bioengineering!  Over this relatively short period, the department has transitioned from a nascent effort launched in 2004 with

🚨New Paper 🚨 Bram et al. identified how nanoparticle charge interfaces with the cellular glycocalyx, dramatically affecting nanoparticle delivery. This enabled a new approach to improve nanoparticle targeting! 🔗 doi.org/10.1002/adma.2…

🚨New Paper🚨 Want to deliver nanoparticles outside the liver? Bram et al. identified nanoparticle corona proteins that liver macrophages use to capture nanoparticles. This discovery helped increase delivery to organs outside the liver by 12x! 🔗rdcu.be/emdGS

The Binding Affinities of Serum Proteins to Nanoparticles | Journal of the American Chemical Society University of Toronto U of T News pubs.acs.org/doi/10.1021/ja…

🚨New Paper🚨 Ben Stordy and Zahra Sepahi answer the question: Why don't nanoparticles deliver to target cells? For details, see the tweet below: