We've released La-Proteina fully open source! New blog and source code available on our digital biology research site and github.

New research shows certain mitochondrial DNA mutations occur before cancer develops and are not always random. These mutations can contribute to therapy resistance in pediatric leukemia. ow.ly/V39G50WViNa

Interested in a career in biomedical research or research information technology? Don’t miss the St. Jude Virtual Research Career, Education & Training Fair on September 25! Connect with faculty, trainees, and recruiters, and discover new opportunities to advance your career.

New Article! Selecting aminoacyl-tRNA synthetase/tRNA pairs for efficient genetic encoding of noncanonical amino acids into proteins bit.ly/4neyf58

New online! A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR bit.ly/4pAqt7k

We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published nature! Links to paper and tutorial below.

Excited to share the newly published work from the lab, which offers insights into the specificity and evolution of a recently discovered family of aminoacyl-tRNA deacylases. academic.oup.com/nar/article/53…

Unannotated translation products are widespread in model E. coli biorxiv.org/content/10.110… #biorxiv_micrbio

A compelling illustration of the difference between mRNA abundance, ribosome density and protein abundance.

Nature research paper: Design of facilitated dissociation enables timing of cytokine signalling go.nature.com/474cS0E

New paper from Channing Der Der Lab at UNC in Science Signaling Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer science.org/doi/10.1126/sc… "almost one-third of ERK-regulated genes were also regulated by MYC in PDAC cells"

Our 2nd J. Am. Chem. Soc. paper today! Using structure-guided design to create a covalent ligand targeting the FMN riboswitch. The compound is an inverse agonist linked to changes in RNA folding. Grateful for Chungen and Rob Batey’s group collaboration. 🔗 pubs.acs.org/doi/10.1021/ja…

📢📢A new preprint from David Baker labs is here👇👇 What if a single AI model could design RNA sequences and predict protein-DNA binding better than specialized tools?bioRxiv Institute for Protein Design "RNA sequence design and protein–DNA specificity prediction with NA-MPNN"

Absolutely true and beautifully said. The original video she mentions is from Scott Adams, but her sincerity and passion make this version far more persuasive than that master persuader. Focus on the desired outcome, not the work required, and you can move mountains.

Key DNA repair enzyme PARP1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1 nature.com/articles/s4158…

Short explanation of the physics Nobel Prize 2025 In classical mechanics you can know where a particle is and its momentum at the same time. In Quantum mechanics you can't. All information is in the wavefunction. Even if a particle is trapped, part of the wavefunction.. 🧵1/7

Absolutely gorgeous! This is the kind of biological beauty responsible for setting the energy resistance (éR) level in your mitochondria, enabling the transformation of food into the energy that powers your energetic self. ERP: authors.elsevier.com/a/1luVK5WXUlaY…

Excited to share our more recent preprint, on the role of tRNA modifications in stress granule assembly and melanoma metastasis! Congratulations to Riley Hughes and thank you to all the amazing co-authors and collaborators! biorxiv.org/content/10.110…

End-to-end automation of repeat-target cryo-EM structure determination in CryoSPARC biorxiv.org/content/10.110… #biorxiv_biophys

Two back-to-back stories on mitosis led by my incredible postdoc Kruno Vukušić at Ruđer Bošković Institute, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in Nature Communications doi.org/10.1038/s41467… doi.org/10.1038/s41467…