🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

🚀Super excited to share results from our joint study w/ Ocampo Lab showing brain-specific partial reprogramming ameliorating cognitive decline. More evidence for the CNS potential of reprogramming, as we saw in Alzheimer's previously! (as did Altos Labs) prnewswire.com/news-releases/…

Online Now: ZNF574 is a quality control factor for defective ribosome biogenesis intermediates dlvr.it/TKbBFn

kana uses WebAssembly and other technologies to efficiently analyze large single-cell datasets in the browser kanaverse.org/kana/

Kang et al. (2025) NF-κB-mediated developmental delay extends lifespan in Drosophila PNAS. 122(19):e2420811122. doi: 10.1073/pnas.2420811122.

专业脊椎治疗师教你瞬间缓解腰痛的拉伸法。亲测有效！久坐党必看！

Brilliant work Hua Bai Perrimon Lab showing that delayed developmental timing - without changing the growth rate - extends lifespan in flies. A key developmental program linking development to longevity is NF-κB signaling a regulator of inflammation. pnas.org/doi/10.1073/pn…

Molecular machineries shaping the mitochondrial inner membrane | Nature Reviews Molecular Cell Biology nature.com/articles/s4158…

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

Today, we’re announcing the first major discovery made by our AI Scientist with the lab in the loop: a promising new treatment for dry AMD, a major cause of blindness. Our agents generated the hypotheses, designed the experiments, analyzed the data, iterated, even made figures

New 30% mouse lifespan extension paper just dropped! Another example of rapamycin + something increasing mouse lifespan more than rapamycin or something alone. In this case, the something is trametinib, an anti-cancer drug:

Introducing the world's first reasoning model in biology! 🧬 BioReason enables AI to reason about genomics like a biology expert. A thread 🧵:

I agree with David in seeing ageing as a software problem, namely a software design flaw. However, I see ageing as a programmatic process that results not from the corruption of the software but rather from software programs that run-on. genomebiology.biomedcentral.com/articles/10.11…

See post from Brian Calvi below. Flybase at IU is setting up a means to support Flybase efforts in the US.

You’re right, and the Church lab has also previously found a single factor (SRSF1) to induce cellular rejuvenation: biorxiv.org/content/10.110…

Online Now: Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma dlvr.it/TLKJXg

Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis | Nature Cell Biology nature.com/articles/s4155…

Since there appears to be no surveillance mechanism to prevent translation of mRNAs with aberrant ends, understanding how defects in translation elongation arise, are recognized, and resolved is critical for developing an integrated view of mitochondrial protein synthesis quality

IS AGING PROGRAMMED? I recently debated this with the brilliant Aubrey de Grey, moderated by Nathan S. Cheng thinks you should work on aging. at Vitalist Bay in Berkeley. Check it out! Here is a humorous trailer; the full video is linked below.