#Yeast cell created with an over 50% synthetic #genome can survive and replicate similar to wild type. See below a collection of papers presenting this half-synthetic yeast and showcasing the #SyntheticYeastGenomeProject (Sc2.0) SGD Project @[email protected] (bsky too) 🧵

“Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast” @cellcellpress cell.com/cell/fulltext/… Patrick Cai

“Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast” Cell Genomics cell.com/cell-genomics/… Patrick Cai

“Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains” Cell Genomics cell.com/cell-genomics/… Johns Hopkins Bloomberg School of Public Health Srinivasan Chandrasegaran Jef Boeke Weimin Zhang

Biologists have produced a strain of yeast whose genome is more than 50% synthetic DNA go.nature.com/3Qtp2a3

An international team of scientists led by Patrick Cai are one step closer to re-writing world’s first synthetic yeast genome. The Sc2.0 team have now recreated every chromosome in baker's yeast from scratch and combined 6.5 of them in a functional cell. 👉manchester.ac.uk/discover/news/…

A strain of yeast has had half its DNA replaced with artificial chromosomes in a major step towards creating the first complex cell with an entirely synthetic genome newscientist.com/article/240176…

Very proud of our November issue presenting the amazing work by the Sc2.0 consortium. Took me back to my #igem (2006) roots and I know this collection will be a landmark in synthetic biology. cell.com/cell-genomics/…

Check it out now in #Cell #Genomics Open Access - Rise of synthetic #yeast: Charting courses to new applications community.alliancegenome.org/t/cellpress-op…

How do you build a synthetic yeast genome with thousands of designed changes and a new-to-nature genome diversification ‘scramble-ing’ mechanism?

Congratulations to all the consortium members for their hard work and contributions towards a landmark achievement in synthetic biology! Paulsen Lab Sc2.0

Now online! Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions dlvr.it/SyZRQf

Researchers have achieved a significant milestone by successfully integrating more than seven synthetic chromosomes into a single yeast cell, yielding a strain with over 50% synthetic DNA that can survive and replicate similarly to wild yeast strains: synbiobeta.com/read/its-alive…

It’s a great pleasure to see the tRNA neochromosome finally reaching the light of day at Cell! I’m sharing co-first authorship with Daniel Schindler, with Patrick Cai at the helm and under the guidance of Jef Boeke. Find the article here: sciencedirect.com/science/articl…

Now online! Design, construction, and functional characterization of a tRNA neochromosome in yeast dlvr.it/Syc6fM

Congrats to the Sc2.0 community on this huge achievement. Just wait for our Oxytricha trifallax 2.0!!

We finally finished our synthetic chromosome! Tom Ellis Glen Gowers I'm just going to collapse in this corner now... cell.com/cell-genomics/…

Scientists Ben Blount UoN Life Sciences & Tom Ellis @Imperialcollege are poised to create the most advanced “synthetic” organism ever made — a baker’s yeast that is controlled entirely by human-made genetic instructions. Read more The Times and The Sunday Times ▶️ ow.ly/hTEb50Q6nZ9

A yeast strain with over 31% synthetic genome displays normal morphology and budding behavior >>> bit.ly/47pzsPr Cell Press Jef Boeke Patrick Cai Sc2.0

Thank you for highlighting this Twist Bioscience - hope you are keen on many more synthetic chromosome/genome projects!