Post-doc position open in my group. Are you a curious, motivated scientist with good stats background? Would you like to develop creative causal inference methods next to Lake Geneva and surrounded by these mountains? Apply by 30 September! More details: wp.unil.ch/sgg/position-2…

I can only recommend. Exciting projects, amazing colleagues and the view speaks for itself!

Much of the knowledge on the 22q11.2 deletion syndrome stems from clinical cohorts. 🏥 Can we learn more by studying 22q11.2 CNVs in a population-based cohort such as the UK Biobank? 🌍 Find out in our new preprint by Malú Zamariolli! ⬇️ medrxiv.org/content/10.110…

Happy to contribute to the growing research looking into selection bias in the UK Biobank: here, we assess the impact on genome-wide findings and downstream analyses. Our approach and findings 👇

Happy to see our paper about liability scale heritability for low prevalence diseases now out AJHG! The expression is now also available for ascertained traits enabling stable heritability estimation for more traits sciencedirect.com/science/articl… Zoltán Kutalik Dept of Computational Biology, Uni Lausanne ISTAustria

I am very happy to share our review article “Using Human Genetics to Improve Safety Assessment of Therapeutics”, now published in Nature Reviews Drug Discovery. 🧵 nature.com/articles/s4157…

Excited to share that our paper about DNAm mediation through transcript levels is now published Nature Communications! nature.com/articles/s4146… Very grateful to all co-authors Chiara Auwerx Kaido Lepik Eleonora Porcu Zoltán Kutalik for their precious contribution! #omics #GWAS #MendelianRandomization

Most promising method to identify drug targets? 🎯 - #GWAS - #eQTL-GWAS - #pQTL-GWAS - #exome Excited to share our new preprint where we compare all methods including #network approaches (medrxiv.org/content/10.110…) Very grateful to all co-authors Zoltán Kutalik @cauwerx Patrick Deelen

Our pre-print is out 🎉! Read below on how we performed informative clustering of BMI SNPs using PheWAS data of 400+ traits, this revealed several SNP groups that were enriched for distinct trait themes like body lean mass, job type and education, nutritional supplements..🧵👇1/4

📢 New CNV-#GWAS preprint! Excited to share the 2nd chapter of my PhD! 🥳 After previously showing that #CNVs affect continuous traits in the UK Biobank, we asked whether they also modulate susceptibility to 60 common diseases? 👇🏻🧵 tinyurl.com/bdfcdjwe

New year, new paper! 💫📄 Our study on the role of #CNVs as #pleiotropic modulators of #CommonDisease susceptibility is out in Genome Medicine: rdcu.be/dvonQ Major findings (👉🏻 x.com/CAuwerx/status…) + 3 of my favorite new insights based on reviewer’s comments in 🧵

Check it out 🧵👇! Our PWC-MR approach aims to tackle the some of the sources of bias that affect MR causal estimation: heterogenous causal effects & confounding. rdcu.be/dyJ3h Often studied separately, PWC-MR has shown that classifying instruments into clusters...(1/n)