Is there an expected level of biotin-phenol (biotin-tyramide) peptide modification that you should see in your MS analysis from APEX2 proximity labelling experiment?

Canonical AREs are tumor suppressive regulatory elements in the prostate biorxiv.org/cgi/content/sh… #biorxiv_cancer

I’m excited to share our new study of the mechanisms of action of the therapeutic target ONECUT2 in prostate cancer. The protein activates a surprisingly wide range of resistance mechanisms. But we can suppress it with a drug! Prostate Cancer Foundation PCF Science doi.org/10.1093/nar/gk…

Science Magazine alphafold Pamela Ting Perspective: science.org/doi/10.1126/sc…

Enjoying the annual ISSCR meeting #ISCCR2024. Great start with four female speakers in plenary session I! Exciting science and lots of inspiration. Heading from career session to posters into some sunlight ☀️ 🧫 👩‍🔬

Honored to receive both the ISSCR Travel & Merit Award! Great second day and looking forward to more inspiring talks.

7th Max Planck Freiburg Epigenetics Meeting 📅 4 - 6 December 2024 🚩 Freiburg, Germany 👥 Exciting line-up of 27 speakers covering the latest advances in #chromatin research & #epigenetics ⏰ Deadline: September 1st, 2024 events.ie-freiburg.mpg.de

Third day of the #ISSCR2024. Visit today’s posters of my colleagues from RIMLS-Science radboud university. Poster #135 by Danique, poster #359 by Zicong Liu and poster #172 by Hendrik Marks

Very cool proximity labeling method, probes with different labeling radii! #interaction #proteomics

A first step towards a basis for research on #StemCell based #EmbryoModels rdcu.be/dSHtz Nature Cell Biology We hope that this will be useful in this new field where quality control and appropriate criteria are needed

Exciting discussion in our last journal club about an H2O2-independent proximity labeling method & a membrane-impermeable substrate! Also a nice example of a publication sharing the numerous challenges faced along the way! #proteomics #proximity #labeling doi.org/10.1101/2024.0…

Love it when a tagged protein of interest shows the correct localization! #confocal #microscopy

Seeking a #PhD position? Explore exciting projects with us and other groups at IMPRS-LM International Max Planck Research School for Living Matter. Apply now, only a few days left! #PTMs #ADPr #biochemistry #molecularbiology #PhDpositions

#wfh with

This work was led by postdoc, Komal, and research scientist, Louise, @theCrick with the help of lots of others. The link to our biorxiv manuscript can be found here: biorxiv.org/cgi/content/sh… Feedback welcome, thanks for reading! 🙏 (7/7)

How proximal is proximity labeling❓ Using DNA nanorulers we found that TurboID/BioID are largely contact labeling, while APEX2 also bears a major contact labeling pathway in parallel with diffusive labeling. biorxiv.org/content/10.110… Special thanks to Alice Ting for discussions!

iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade biorxiv.org/cgi/content/sh… #biorxiv_biochem

Check out this latest pre-print by Christina Ramelow, MS, (she/her) from Srikant Rangaraju Steven Sloan labs , and co-authors Nick Seyfried biorxiv.org/content/10.110… Dreamt of native-state cell type-specific proteomics and transcriptomics? Introducing SPARO (Simultaneous Protein And RNA Omics).