🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Benchmarking methods integrating GWAS and single-cell transcriptomic data for mapping trait-cell type associations medrxiv.org/cgi/content/sh… #medRxiv

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances nature.com/articles/s4158… #journals #feedly

We are pleased to share our work evaluating some of the latest single-cell platforms, including updated chemistries, in two separate experiments using peripheral blood mononuclear cells (PBMCs). biorxiv.org/cgi/content/sh…

Terminal Genome Viewer (tgv), written in Rust github.com/zeqianli/tgv

Thrilled to announce that our work on Expansion In Situ Genome Sequencing (ExIGS) is now published in Science Magazine! ExIGS allows us to sequence DNA and image proteins with super-resolution directly within single cells. science.org/doi/10.1126/sc…

SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads biorxiv.org/content/10.110… 🧬🖥️🧪 longcallR: github.com/huangnengCSU/l… Nextflow workflow: github.com/huangnengCSU/l…

An atlas of transcription factor-driven gene programs across human cells Teichlab biorxiv.org/content/10.110…

🌟New 🌟Our AI model TranscriptFormer is the first multispecies generative model for #SingleCell transcriptomics. bit.ly/42AvbbS

Analysis-ready VCF at Biobank scale using Zarr. #VCF #Zarr #GeneticVariants #Genomics #Bioinformatics GigaScience academic.oup.com/gigascience/ar…

Pangenome-aware DeepVariant biorxiv.org/content/10.110… #biorxiv_bioinfo

Common variants influencing gene expression, often influence multiple genes, yet GWAS secondary analyses prioritize single causal gene identification. New method introduces a multi-gene eQTL mapping framework biorxiv.org/content/10.110… bioRxiv

A powerful alternative to principal components (PC) to account for population structure in genetic association analysis: spectral components (SPc) Compared to PC, SPc - explain more variation in population structure with fewer components (90% for SPc vs 50% for PC) - more

Polygenic risk score (PRS) tools are getting better and better! Yue Li & team at McGill report a major update to their PRS software, VIPRS (variational inference of polygenic risk scores) — now lightning fast & ultra-efficient. VIPRS reads ultra-compressed LD matrices (MBs not

Various cell types in tissues cooperate in networks that are disrupted in disease nature.com/articles/d4158… #journals #feedly

Pedixplorer: a Bioconductor package to streamline pedigree design and visualization. #PedigreeDesign #PedigreeVisualization #Bioconductor #Bioinformatics 🧬 🖥️ academic.oup.com/bioinformatics… louislenezet.github.io/Pedixplorer/

So excited that our team was awarded an #ERCAdG grant European Research Council (ERC) this year. A testament to the brilliance, hard work and dedication of my present and past teams Human Technopole Wellcome Sanger Institute Cambridge University. 🤩🤩

What if SCALE is a solved problem? 🤔 Sequencing-Free Single-Cell Genomics with STAMP! 💣 Now published in Cell: Our approach for scalable, cost-effective analysis of millions of single cells or hundreds of samples—without sequencing. By replacing sequencing with

🚀 Xaira Therapeutics has just dropped a game-changer for AI-driven biology. Today, we unveiled X-Atlas/Orion, the largest publicly available genome-wide Perturb-seq dataset to date—spanning 8.4 million single cells with perturbations across all ~20,000 human protein-coding

Improving gene isoform quantification with miniQuant nature.com/articles/s4158… 🧬🖥️🧪 github.com/Augroup/miniQu… (no code, only executables, noncommercial license)