An argument on the relationship between #genes, #cells and #embryos, the role of genes in the construction of animals and the creative tension between genes and cells, twins, human nature #TheMasterBuilder #CellsRUs #NotInTheGenes science.org/doi/10.1126/sc…

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/

#cryoEM with energy filter & electron counting significantly increased resolution even for a full size protein like proteinase K. Sub-atomic resolution #MicroED rivals best reported Xray of Proteinase K but by using crystals a billionth the size. A section of the map is shown

8月22日-23日、SS-Fインベンターの研究者同士の交流を深めるリトリートを箱根で開催しました！

Had a blast as always at the #SS-F retreat! Loved the activities and the quintessential picturesque venue #Hakone

Why are so many inherited traits not explained by genome sequence variation? In my PhD work with @wbderry we describe a new mechanism of inheritance in animals that may account for this ‘missing heritability' 🧵nature.com/articles/s4155…

1/8 ❄️🔬Excited to share our latest work published in Nature Communications! Led by Kaitlyn Abe and in colab with Tim Grant, we've discovered a simple, cost-effective way to mitigate sample damage at the air-water interface during grid preparation. #CryoEM rdcu.be/dSWfn

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

An anti-CRISPR that (quite literally) deconstructs #CRISPR – was a pleasure spotlighting this latest discovery from the Davidson Lab in Molecular Cell, with Peter Fineran. Speculation included! authors.elsevier.com/a/1jjHE3vVUPRm…

Strongly absorbing dyes, such as a common food color tartrazine, temporarily render live animal tissues transparent, enabling deep optical imaging of internal structures and activities.science.org/doi/10.1126/sc… #NBThighlight

Top 10 Manu Prakash teachings from his amazing episode of the Night Science Podcast. 1. Science is a sense of wonder; a personal sense of experience. 2. Science gives us increasing agency; you realize it’s like a car you drive with no roads. 🧵⬇️ Manu Prakash Martin Lercher

Kiss😘of the RNAs Excited to share our work on the significance of a ‘kissing loop’ RNA-RNA interactions in driving RNP granule assembly. nature.com/articles/s4155…

【個展のお知らせ】 ジェンダーロールによって「抱えさせられている」女性、男性、性的マイノリティのモヤモヤや悩みを共有し、既存のスクリプトを解体するためのアート展。年齢性別不問です！ 「WRONG HERO」 2024/10/19(土)〜10/27(日) TRiCERA Official prtimes.jp/main/html/rd/p… PR TIMES から

Two years ago we published the discovery of hotspots of novel anti-phage defense systems in the genome of P4 phage satellites, including a mysterious Phage Anti-Restriction Induced System (PARIS). We have now published the mechanism in nature nature.com/articles/s4158…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

The 2024 #NobelPrize laureates in chemistry Demis Hassabis and John Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have

“I love all the proteins so I don’t want to pick favourites." New chemistry laureate, David Baker, spoke about the technology he developed that creates protein structures at the 2024 #NobelPrize in Chemistry press conference today. Watch in full: bit.ly/4eBoGJp