Honored and looking forward to presenting my postdoctoral work on the 53BP1-RIF1-shieldin pathway as part of the ECS3 seminar at IRCM!

Thanks Dongyi and collaboraters!

🚨Job alert🚨 Our lab is looking for a bioinformatics associate to support our work using functional genomic/proteomic approaches (CRISPR screens, proximity proteomics, various Seq approaches). 👇 contact2.mshri.on.ca/hr/DEFAULT.ASP…

the screaming nuclear

Very excited to share a new preprint from the durocherlab! We used AlphaFold2 to exhaustively map the 53BP1-RIF1-shieldin-CST pathway and found a novel RIF1-SHLD3 binding interface essential for pathway function. 🧵below 1/6 biorxiv.org/content/10.110…

We're excited to report a new mechanism of replisome proteostasis cell.com/cell/fulltext/…. 55LCC ATPase/unfoldase complex dependent replisome turnover prevents chromosome instability. Great collaboration by Vidhya K and @RobertLDilley with @FoglizzoMartina and ergiola Zeqiraj.

A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to Raphael Pavani, Veenu Tripathi, and many terrific collaborators including Johannes Walter, Cejka Lab, Wei Wu. See science.org/doi/epdf/10.11…