Modesty comes in more than just our physical appearance. Our entire bodies, personalities, and thoughts should emanate modesty. #Haya

More open access #COVID19 research available from SLAS Discovery. Read A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19 from researchers at Structural Genomics Consortium (SGC): bit.ly/39mbmIm.

#MedTwitter #PathTwitter

12 yo girl with nodule on dorsal finger. Your diagnosis? WSI digital slide: kikoxp.com/posts/3742. Answer & video: kikoxp.com/posts/3831. #Pathology #dermpath #dermatology #dermatologia #dermtwitter #BSTpath

Hey everyone, I’m Sumera Perveen a Postdoctoral fellow in Molecular Biophysics at University of Toronto. I’m here to connect with my colleagues and mentors. Structural Genomics Consortium (SGC) Medical Biophysics University of Toronto #medtwitter University of Waterloo UWaterloo Alumni Waterloo Biology

Very happy to be the editor for the first of the Ciulli Lab Journal Club! Check it out on what’s new in the #PROTAC field! #realtimechem #chemtwitter

Computational chemistry postdoc position open in my group at Structural Genomics Consortium (SGC), University of Toronto, co-supervised by John Irwin John Irwin Chemistry at UCSF to enumerate and screen new areas of the chemical space: bit.ly/3Jgktun Please re-tweet!

Kicking off the SGC's 20th Anniversary Symposium with Dafydd Owen presenting the discovery and characterization of PAXLOVID, an orally bioavailable SARS-CoV-2 main protease inhibitor with in vitro pan-human coronavirus antiviral activity. #20yearsSGC

As Ramadan is near, I first and foremost seek anyone's forgiveness that I may have offended in person or online at any point. I pray Allah unites us all in that which is pleasing to Him. To my brothers and sisters who share the noble vocation of Dawah with whom there may have

Structural and biophysical characterization of a small molecule binding to Cbl-b E3 ligase reveals an intermolecular glue mechanism locking the protein in an inactive state: nature.com/articles/s4200… Levon Structural Genomics Consortium (SGC)

Read my latest #research on #HistonePosttransationalModifications, published with Michael Wiley in AdvancedScience onlinelibrary.wiley.com/doi/full/10.10…

Over the past 4 years, we applied machine learning to DEL screening data from 20 unprecedented targets. We found verified hits for half. Have a read!

CACHE symposium happening right now, alot of learning…

All participants to CACHE #1 who agreed to be de-anonymized were invited to join the overview manuscript. The first of a long series to serve as a resource for future developments in virtual screening workflows. doi.org/10.1101/2024.0… Structural Genomics Consortium (SGC) Conscience #compchem

Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2 #Docking pubs.acs.org/doi/10.1021/ac… Cheryl Arrowsmith Levon Sumera Perveen, PhD Matthieu Schapira Structural Genomics Consortium (SGC) #JCIM Vol64 Issue13 #Bioinformatics

Announcing CACHE2 results! Crowdsourcing and conventional methods did as well as novel ML. Teams started from 4 fragments in the PDB. We tested their predictions and found double-digit µM hits. This is the state-of-the-art. Structural Genomics Consortium (SGC) Conscience bit.ly/4dTPBzO

All participants to CACHE challenges are invited to join the overview paper. pubs.acs.org/doi/10.1021/ac… CACHE#1 learnings: -Workflows were diverse. -Most top methods included some ML. -Hits were weak: lots of room for improvement. Structural Genomics Consortium (SGC) Conscience #compchem