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Ever heard of a 7TMR, which is not a GPCR? We provide the molecular basis for the ‘quirkiness’ of the unique DARC receptor, just out in Cell !! Shout out to Shirsha Basavraj khanppnavar Ramanuj Banerjee Korkhov Lab Arun K. Shukla and others involved. cell.com/cell/fulltext/…

Excited to share this latest publication from our lab, highlighting the molecular intricacies of a unique seven-transmembrane receptor. Congratulations to the authors involved💐. cell.com/cell/fulltext/…

#VineshPhogat #Paris2024 #Olympics Team India

Mahabharat. Years ago. Still relevant.

Delighted to share our study on promiscuous chemokine binding at a chemokine receptor, now published in Molecular Cell!!! Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2: Molecular Cell cell.com/molecular-cell…

Very excited to share our latest work on the molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2: Molecular Cell!!! cell.com/molecular-cell…

Excited to share our latest findings on CXCR2 chemokine receptor promiscuity, revealing that a conserved motif in both the receptor and ligand governs the selective binding of multiple ligands to a single receptor. Congratulations to everyone involved. cell.com/molecular-cell…

The Paradox of Knowledge

#authorinterview Sudha Mishra & ANNU DALAL from lab of Arun K. Shukla BSBE@IITK Mehta Family Center for Engineering in Medicine IIT Kanpur talks about their work on "Decoding CXCR2: Unravelling Chemokine Promiscuity for Targeted Therapeutics" published in Mol Cell. biopatrika.com/academia/resea… via Biopatrika

Delighted to share our latest study on chemokine receptors, now published in Nature Communications !!! Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system | Nature Communications nature.com/articles/s4146…

Delighted to share our latest work on the structural visualization of small molecule recognition by CXCR3 and uncovering of dual-agonism in the CXCR3-CXCR7 system published in Nature Communications!! nature.com/articles/s4146…

Excited to share our latest cryo-EM structure of CXCR3 in complex with small-molecule agonist. Our findings reveal that these agonist induces transducer bias in CXCR3 and, interestingly, exhibits dual agonistic properties at the CXCR7. nature.com/articles/s4146…

Delighted to share our latest study on the complement anaphylatoxin receptors 😎!!! Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors biorxiv.org/content/10.110…

Excited to share our latest study, now available online. Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors biorxiv.org/content/10.110…

Excited to present our preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Check it out! biorxiv.org/content/biorxi…

2/n We also observe that JR14a and SB290157, the so-called small molecule antagonists of C3aR, are actually agonists, which aligns with recent reports from other labs! Surprisingly, we discover that unlike JR14a, SB290157 is strongly selective for the human C3aR over mouse C3aR!

3/n The species-specific pharmacology is not limited to synthetic ligands but also extends to the natural C3aR agonists! For example, TLQP21, a VGF-derived, non-C3a agonist of C3aR, also shows a dramatic preference for the mouse receptor, especially in the beta-arrestin assay!

7/n In order to understand the fascinating pharmacology and biology of these incredibly versatile receptors, we reconstituted a broad set of agonist-receptor-G-protein ternary complexes in various combinations, and determined a total of seventeen cryo-EM structures😎.