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Why do many neurons exhibit a smooth continuum of molecular identity? We find that graded heterogeneity in metabotropic glutamate signaling could generate diverse synaptic responses within a single cell type. Many thanks to our collaborator! Evan Macosko biorxiv.org/content/10.110…

Really excited to get out wonderful work from my equally fantastic postdoc Leena Ali Ibrahim on how bottom up signaling facilitates the establishment of top-down connectivity in NGF cells. Read it in Biorxiv! biorxiv.org/content/10.110…

1. Our work showing that GABA-receptive microglia selectively sculpt inhibitory synapses during development is out Cell: authors.elsevier.com/c/1dMWhL7PXe~wk Wonderful collaboration w/ beth stevens Sandeep Robert Datta Farhi lab @RichBonneauNYU Harvard Medical School Broad Institute thread⬇︎

Take a look at our recent work in Neuron Neuron examining the contribution of early thalamic inputs onto L1 interneurons in the establishment of top-down connectivity in V1 cortex authors.elsevier.com/a/1dgve3BtfGzk…

Tips for setting up a new two-photon rig in a lab from a recidivist in the matter OR don’t repeat my mistakes. The experience could be helpful given our effort for high throughput at The Allen Institute. I will add more items to this thread as they come. share your tips too!

✨ 🔬 #OpenScope: A shared observatory for #neuroscience — is now accepting experimental proposals from external scientists. #openscience ☑️ Letter of Intent Due: 9/12/2022 ☑️ Proposal Due: 11/7/2022 Visit: alleninstitute.org/what-we-do/bra…

Check out our new biorxiv paper led by Sherry Wu and Emily Fishman targeting the breadth of cortical somatostatin cells and showing their remarkably selective circuitry. biorxiv.org/content/10.110…

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease science.org/doi/10.1126/sc… Delighted for Fumito Endo and many thanks to the team that made this possible!

# Chinese scholar # Old Montreal fire A large fire broke out in a historical building in Old Port District of Montreal, Canada at 5:45 am on Thursday. 6 people remain missing, among which is a promising young Chinese scholar, Dr. An Wu, who came to Montreal for a conference.

Big congrats to my mentor Gord Fishell! Well deserved!