Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles Nature Communications nature.com/articles/s4146…

Mechanotransduction in the nucleus Multiple TFs transmit mechanical forces into transcriptional regulation. Nuclear shape, size, and chromatin abnormalities are common features of many diseases.

In a preclinical mouse model of bullous pemphigoid, keratinocyte-specific Myd88 knockout significantly decreases disease severity and reduces serum levels of IL-4 and IL-9 Nature Communications nature.com/articles/s4146…

Preprint: SARS-CoV-2 induces long-lasting neuroimmune and metabolic disturbances that may underlie persistent symptoms and contribute to premature neurodegeneration in African green monkeys researchsquare.com/article/rs-713…

Single-cell multitargets and mRNA sequencing enable the simultaneous profiling of transcriptome and up to six histone modifications in individual cells Rugg-Gunn Lab Science Advances science.org/doi/10.1126/sc… science.org/doi/10.1126/sc… preview by Haiqi Chen

Excited to share our latest paper @NatureMethods We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4). nature.com/articles/s4159…

A second #BriefReview in the Human and Clinical Immunology Special collection discuss the future of chimeric antigen receptor T (CART) cell therapy including how the field is moving into the treatment of solid tumors and other diseases beyond cancer. 🔗 ow.ly/ahLK50Wzso5.

nytimes.com/2025/07/30/opi…

I have an open door policy but people coming into my office and opening my cabinet and drawers to take stuff is not okay. This just means I have to lock my doors at all times

Online Now: A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers dlvr.it/TMMSDf

A new Science #Immunology study in mice suggests that TRPV1+ vagal #sensory neurons promote survival after #InfluenzaA infections by regulating proinflammatory cytokines and myeloid cell recruitment to the lungs. scim.ag/47aTRKt

Galectin-9 is an immunotherapy target for modifying regulatory and exhausted T-cells in CLL nature.com/articles/s4146… Nature Communications

A cost-effective ultra-high-throughput cytometry-based framework for the detection of physical interactions between cells, along with the characterization of complex cellular landscapes Nature Methods nature.com/articles/s4159… nature.com/articles/s4159…

Transferrin receptor–targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA Science Magazine science.org/doi/10.1126/sc…

Happy #3DThursday! I'm quantifying some microglia morphology and trying to figure out why sometimes these cells start eliminating neuronal synapses🧐 Markers: IBA1 for microglia, PSD95 for synaptic protein. Z-stack image acquired with ZEISS Microscopy, analysis with Imaris 3D/4D Imaging

Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice dlvr.it/TMMdyW #immunology

Optimal Pairing of Binder and Costimulatory Domains Improves Dual CAR T Cell Efficacy - Targeting both CD19 and CD22 with optimally paired signaling domains (CD19 = 4-1BB, CD22= CD28) exhibit superior tumor control #TCell #tcellrx #immunotherapy Jim Riley E. John Wherry

Integrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation Cell Systems cell.com/cell-systems/f… Christoph Bock Lab @ CeMM & MedUni Vienna Peter Traxler

Commentary Cancer Cell Nicole Scheff Rethinking relief: Targeting sensory neurons to combat cancer and pain cell.com/cancer-cell/fu…

A new #mRNA vaccine for #HIV that encodes a membrane-anchored version of the viral envelope trimer avoids off-target responses towards the Env base and produces potent immune responses in animals. La Jolla Institute Prof. Shane Crotty scim.ag/4kXMbOZ