Scientists identified chemokines expressed by osteosarcoma that enhanced CAR T-cell homing, presenting a promising new strategy to improve antitumor activity. This work is a significant step forward in the development of immunotherapy for solid tumors. ow.ly/Y7pn50SRv35

Research from @HCMefford in Nature Communications has demonstrated the benefit of DNA methylation “episignatures” as fingerprints to track the cause of unsolved rare DEE cases to their relevant gene.  Learn more: stjude.org/media-resource…

Researchers identified distinct molecular subtypes of B-ALL that occur in different age groups explaining why cure rates vary between children and adults. The study suggests treatments should be tailored based on underlying molecular groups beyond age. ow.ly/k2SL50SSlU2

Inclusion and excellence have always been part of our DNA. Forbes recognized St. Jude in the Top Ten on their 2024 list of America’s Best Employers for Women. #WomenInScience #BestEmployersForWomen #ForbesList ow.ly/nlZh50ST6sP

Researchers found a link between multisystem inflammatory syndrome in children and COVID infections. Understanding this connection could lead to better diagnosis and the development of targeted treatments. ow.ly/bxBR50SU9qk

Join us Thursday, 8/15, at 12 pm CT/1 pm ET to hear rising stars of cancer research, Kyle Daniels, PHD, and Evan Weber, PhD present research on pediatric cancer therapies. Register here: ow.ly/qx4450SUbTB

Blood Journal Thanks to Blood Journal for highlighting our paper on the effect of #BMTsm on cardiac fibrosis in #SickleCell disease. Here is a brief thread of our main findings x.com/AkshaySharmaMD…

Researchers identified genetic predictors of relapse risk in standard risk B-cell acute lymphoblastic leukemia, providing a blueprint for improving treatment outcomes. ow.ly/75s650SV0FO

A recent study identified distinct age-dependent antibody responses that correlate with disease severity, providing targets to aid the design of future vaccine clinical trials. Read the paper in Immunity. ow.ly/ztOo50SWiBw

Scientists discover high expression of OLAH enzymes drive life-threatening immune responses in severe respiratory viral diseases. Early detection may help determine if patients need more intense initial treatment. ow.ly/5kn450SX5fE

Findings from St. Jude and CHOP Research reveal genetic changes in non-coding DNA drive 60% of genetic changes in T-ALL, allowing investigators to better identify high-risk patients who are more likely to relapse. ow.ly/Ah1X50SXOzH

For the first time, PARP inhibition has been used to treat a patient with neuroblastoma harboring a BARD1 mutation. The case study has implications for integrating genomics into pediatric cancer care to find vulnerabilities for targeted therapies. ow.ly/vh8Q50SY2Kb

Scientists found T-follicular helper cells determine the effectiveness of vaccine-induced flu immunity. Research suggests an improved method for developing flu vaccines that would increase efficiency and prevent helper cell-mediated suboptimal responses. ow.ly/uIYl50T2fE0

Another opportunity St. Jude Research! Seeking a senior scientist 👨‍🔬👩‍🔬to lead a brain #organoid core to support researchers in Ctr for Peds Neuro Dz Res - collaborative work with multiple PIs to understand & treat #RareDisease 🧠🧬 talent.stjude.org/research/jobs/…

Early-career researchers and trainees in childhood cancer survivorship: the 2025 Childhood Cancer Survivor Study Career Development Award is open for applications! Apply by Oct. 7 to advance your research and make a difference in survivorship care. ow.ly/Bf6X50T6yUV.

Congratulations to Nidhi Bhatt, MD, the 2024 St. Jude Outstanding Physician. Her work with the St. Jude Global Initiative and Pediatric Hem/Onc Fellowship embody the spirit of compassion, care, leadership and innovation that are hallmarks of the award.

Don’t miss the annual Pediatric Palliative Oncology Symposium on 9/26. The seminar will feature a panel of healthcare professionals working in institutions worldwide to discuss "High Quality Pediatric Palliative Care Delivery for Every Child, Everywhere". ow.ly/fXEL50T9LpH