Switch-like genes, showing "on" or "off" expression in different people, include 473 linked to cancer, immune, metabolic, and skin diseases. Only 8.5% are universally switch-like across all tissues; 91.5% are tissue-specific. nature.com/articles/s4146…

Elite rowers have a markedly higher prevalence and incidence of atrial fibrillation (AF), particularly those with a high AF polygenic risk score. academic.oup.com/eurheartj/adva…

A 1.9–3.3% increase in global muscle mass in humans is associated with a 4.1 ± 5.8% reduction in fat mass in studies lasting from 2 weeks to 3 years. link.springer.com/article/10.100…

Uncovering the Molecular Landscape of Physical Activity: Proteomic Insights from the UK Biobank medrxiv.org/content/10.110…

Polygenic prediction of cardiorespiratory fitness: The HUNT Study medrxiv.org/content/10.110…

GWAS identifies 70 genetic variants linked to leisure, work, and home-time physical activity nature.com/articles/s4158…

Excited to share our new paper in Skeletal Muscle! We show that large Maf transcription factors can robustly induce MYH4, normally silent in humans. In human muscle, Mafa and Maf expression correlate with fast fiber content.doi.org/10.1186/s13395… #myotwitter

Happy to contribute to the study led by fujiryo, showing that large MAFs may unlock latent potential for type IIb myofiber development in humans. This may help enhance power performance and combat age-related fast-twitch fiber loss. LJMU Sport Science …eletalmusclejournal.biomedcentral.com/articles/10.11…

Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle “This discovery… suggests potential strategies for enhancing muscle performance and mitigating fast-twitch fiber loss associated with aging and muscle

A large-scale genome-wide analysis identifies 53 genetic variants associated with frailty nature.com/articles/s4358…

WILD. This paper suggests humans can awaken a dormant muscle fiber type (IIb) - the fastest we know of, but it is completely non-existent in humans (highly abundant in cats, cheetahs, mice, etc.). Some quick context. Humans have two major muscle fiber types: Slow and

New from our lab: Methodological insights on single-fiber SDS-PAGE methodology for muscle fiber phenotyping - how fiber count and selection strategy (random vs. ordered) determine precision in muscle fiber typing. #musclefibers #myotwitter nature.com/articles/s4159…

Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength nature.com/articles/s4358…

Our new paper: Genetic Factors of Elite Wrestling Status: A Multi-Ethnic Comparative Study In collaboration with Naoki Kikuchi pubmed.ncbi.nlm.nih.gov/40869954/

ACTN3 genotype influences androgen response in developing murine skeletal muscle science.org/doi/10.1126/sc…

Cold Stress Regulates Muscle Development and Promotes Muscle Fiber Transformation by Regulating Mib1/Notch Pathway imrpress.com/journal/FBL/30…

Our latest: The ACTN3 R577X Nonsense Allele Is Underrepresented in Professional Volleyball Players and Associated with an Increased Risk of Muscle Injury in Female Players mdpi.com/2073-4425/16/9…