We were founded as a unique partnership between science funders Medical Research Council Cancer Research UK Wellcome and three of London’s major universities UCL Imperial College London King's College London. Our continued funding will help strengthen these relationships. crick.ac.uk/news/2022-07-1…

Our latest paper is finally out in JBC! We identified a new mammalian substrate of mTORC1 - Unkempt, and discovered its role in controlling cell shape.

@HarvardCellBio UW Genome Sciences Gygi Lab Research Highlight: Proteomics reveals small molecules’ secrets, via Nature Reviews Drug Discovery nature.com/articles/d4157…

Scientists at the University of Sheffield believe they are a step closer to developing a nasal spray to treat motor neurone disease and some forms of dementia. itv.com/news/calendar/…

How do we go about generating neural cell types in vitro from human pluripotent stem cells? Generally, we leverage relevant morphogen pathways and iteratively modulate them by trial and error to generate a cell population of interest. This is tedious and we yet have to learn

Taking a little break from science 🇲🇽

Working with ERUK and other rare disease charities is a major aim for our rare disease node, so looking forward to this exciting project!

We have an RA post available to work in our new mTOR Pathway Diseases node, part of the NIHR/MRC UK Rare Disease Research Platform. Deadline in 2 weeks. Please RT! Institute of Psychiatry, Psychology & Neuroscience

I am thrilled to announce that our paper on identifying a new function of the master energy homeostasis regulator PGC-1a is out in Nature Comms! Such a fantastic effort by all people involved! Lydia Castelli Guillaume Hautbergue Hautbergue Lab Prof Heather Mortiboys nature.com/articles/s4146…

Really happy to be part of this fantastic work by @rebecca_morr et al on LRRK2 in macrophages!

Researchers at the Crick, @UCL and MSD have identified a potential treatment target for a rare genetic type of childhood epilepsy. Read more about the study from Marisol Sampedro-Castaneda and Sila Ultanir 👇 crick.ac.uk/news-and-repor…

Really happy to be part of this amazing #research done by Marisol Sampedro Castaneda et al. We identified an exciting new substrate of the epilepsy-linked kinase CDKL5 - Cav2.3 and characterised the effect of phosphorylation on its function. Nature Communications nature.com/articles/s4146…

I am excited to share that I will be starting my lab at UCL as part of the LMCB UCL Laboratory for Molecular Cell Biology in 2024. We will be studying how cis-regulatory elements controls cell fate decisions during development. We are recruiting at all levels. Learn more and reach out!

Recent publication from our lab showing that CDKL2 phosphorylates CDKL5 substrates in brain. Congratulations to Margaux! nature.com/articles/s4138… The Francis Crick Institute crick.ac.uk/news-and-repor…

I am excited to share our latest paper on Cdkl5 and the identification of Cdkl2 as a compensating kinase. Fantastic work by Margaux Silvestre, PhD! Happy to be part of this! nature.com/articles/s4138…

Our new paper modelling #mitochondrial disease in Drosophila is now available. UPR and #ATF4 activation in the brain depends on the severity of mitochondrial complex I loss. journals.biologists.com/bio/article/13…

A fantastic must read! I am really happy to be part of this work by Lin and Jenn Scribbins (Dodd) et al!

📢Introducing the #Onein100 campaign To coincide with our first anniversary as the Epilepsy Research Institute, we are thrilled to launch our One in 100 campaign to raise awareness and secure vital funding for epilepsy research. Join the mission today: epilepsy-institute.org.uk/onein100/?utm_…

I am running my first ever half marathon - London Landmarks Half Marathon in April. I am doing this with the support of Epilepsy Action UK and fundraising for them. If you would like to contribute to making a difference, please donate on my page: justgiving.com/page/simo-miha…

It’s been a very interesting day of workshops at HUPO 2025. Now time for the welcome plenary lecture. Human Proteome