Take a look at an interactive demo of the SILCS technology in use for ligand optimization. See the step by step process in action including the information our FragMaps give you. #pharmaceuticaldrugdesign #CADD #Bioinformatics #ComputationalChemistry landing.silcsbio.com/newlandingpage…

#ThrowbackThursday to our study on extending SILCS to RNA targets! 🧬📄 Read more: ncbi.nlm.nih.gov/pmc/articles/P… #ComputationalChemistry #MolecularModeling #ComputationalDrugDesign #ChemicalInformatics #RNADrugDesign

Our team is going to be in Montreal for a conference hosted by Chemical Computing Group from June 25th-June 28th. Let us know if you'll be in the area during that time! #pharameuticalresearch #drugdiscovery

Join us on July 10th @ 2:00pm EST for our webinar as SilcsBio launches the web app version of CGenFF! Learn about CGenFF's role in deriving precise force field parameters for organic molecules. Register now: us02web.zoom.us/webinar/regist… #CGenFF #Webinar #SilcsBio

SilcsBio 2024.2 Version is officially released. Check out the new features here: lnkd.in/dgi-asCc

Covalent drug design paper. Reactive Site Detection: SILCS-Monte Carlo for accurate cysteine identification. Warhead Optimization: ML models to rank warhead effectiveness. Integrated Workflow: SILCS-Covalent for comprehensive insights. pubmed.ncbi.nlm.nih.gov/37115781/

🚀 Beta Testers Wanted for SILCS-Covalent! We've developed a new covalent workflow module to enhance drug discovery. Check out our publication: lnkd.in/e_pfyimd. Interested? Reach out at [email protected] for details and incentives!

🎥 Missed the SILCS-WATER webinar? Watch the recording now! Learn how SILCS-WATER provides exciting possibilities for understanding water's role in protein-ligand interactions. 📽️ youtu.be/wrTJOzMrH2w Thanks to Anmol Kumar and Alex MacKerell #CompChem #DrugDesign

🌟 Join Us for the SILCS v2025 Release Webinar! 🌟 Key Highlights being coverd: - Precise docking w/ water inclusion - Improved ML-based hotspot ranking - Streamlined multi-cofactor simulations 📅 Feb 13, 2025, 12 PM ET Register: events.teams.microsoft.com/event/214c66e6… #compchem #drugdesign

SILCS v2025 Release Webinar Recording is Now Available! 🎬 Missed the live session? Catch up now to explore📺: silcsbio.com/whats-new-in-s… 📄 Read full release notes: docs.silcsbio.com/2025/release.h… #CompChem #drugdesign

ACS Spring 2025 is just two weeks away! The SilcsBio team will be in San Diego! We’ll be at the ✅ Expo with a booth, plus we have a✅ talk and a ✅ poster session lined up. Stay tuned for details on our schedule. If you’re attending, let’s connect! 👥 #CompChem #ACSSpring2025

SilcsBio Team will be at #ACSSpring2025 🎤 #Talk by Asuka Orr : SILCS for ADC development 📅 Sun, Mar 23 | ⏰ 4:30 - 4:55 PM 📜 #Poster by Abhishek Kognole : Speed vs. Accuracy in CADD 📅 Tue, Mar 25 | ⏰ 7:00 - 9:00 PM |📌# 865 📍Booth at #ACSExpo # 3951 #CompChem #DrugDesign

KRAS G12D: Once Undruggable, Now Predictable with SILCS See how our platform delivers: 🔹 Binding site ID from apo structures 🔹 Accurate pose refinement + LGFE scoring 🔹 Atom-level SAR insights #CompChem #DrugDesign #SILCS silcsbio.com/cracking-kras-…

⚛️ CGenFF Web App (cgenff.com) has helped 10K+ users generate topology and parameters for 100K+ molecules. Next week, a special opportunity is coming for industry users to try it with fewer barriers. 📅 Details drop July 1. #CGenFF #CompChem #GROMACS #CHARMM

Harnessing computational technologies to facilitate antibody–drug conjugate development #machinelearning #compchem nature.com/articles/s4158…

New Perspective in Nature Chemical Biology: physics-based computational methods like MD and SILCS enable predictive, rapid design of ADCs—optimizing linker–site–DAR choices & payload–antibody interactions. #ADC #Biologics #CompChem #SILCS Alex MacKerell nature.com/articles/s4158…

Beyond on overview of physics and ML-based methods applied to antibody-drug conjugates (ADCs) the paper presents calculations showing how MD simulations and the SILCS technology may be used to facilitate ADC development using utilities available from SilcsBio

Run CGenFF for Just $1 per Molecule (July Only) Industry users can now generate topology and parameters for small molecules for just $1 each. Explore #CGenFF with minimal commitment and maximum flexibility. app.cgenff.com #CompChem #MolecularModeling