The first paper from our lab at MPI for Multidisciplinary Sciences is online! Have a look if you’re interested in very high-resolution (20 bp!) contact matrices and the role of loop extrusion in enhancer-promoter interactions: nature.com/articles/s4146…

📣 Happy to share our new pre-print: The Mediator complex regulates enhancer-promoter interactions. biorxiv.org/content/10.110… Short thread below ⬇️ (1/6)

We're very proud of our team member Ngoc Caotranbichngoc, who was awarded a PhD fellowship from the Boehringer Ingelheim Fonds! 🎈

📣Happy to see our review out: @MagdalenaKarp and I discuss evidence from the last few years that shows that loop extrusion plays an important role in the regulation of enhancer–promoter communication and gene expression. Open access link: sciencedirect.com/science/articl…

📣 Excited to share our latest work, in which we set out to reconstitute #3Dgenome folding in vitro to get more insight into the underlying mechanisms. Summary of our surprising findings below! 1/7 biorxiv.org/content/10.110…

A short summary of the paper is available in this Research Briefing 🙂 rdcu.be/dgzrd

Very happy to share the final version of our paper in Nature Genetics, in which we reconstitute chromatin domains and find that nucleosome positioning plays an important role in higher-order folding of chromatin: nature.com/articles/s4158…

Happy to share our #BiochemSocTrans review: Elisa Oberbeckmann and I discuss how in vitro reconstitution studies have contributed to our understanding of genome organisation and reflect on possible future applications. doi.org/10.1042/BST202…

📣Preprint alert! We have studied the formation of pair-wise and multi-way enhancer-promoter interactions in the #3Dgenome in a lymphoid-to-myeloid transdifferentiation system and learned interesting new things about their function in #GeneRegulation. 1/10 biorxiv.org/content/10.110…