Thrilled to be a part of this year's JCC cohort!! I am immensely grateful to my mentors for their support, especially my postdoc advisor Bernardo Sabatini Bernardo Sabatini and PhD advisor Sung Han Sung Han, and countless friends who helped with the proposal. Happy to pay it forward!!

1/6 Exciting news! Our paper is now online in Cell! We've developed PRESYNAPTIC sensor and silencer for peptidergic transmission. The sensor detects LDCV release events, and the silencer specifically degrades neuropeptides inside the LDCV. authors.elsevier.com/a/1jTSjL7PXqREw

Congrats Dongil and Sung for this beautiful work! Important tool for the community!!

Very proud of this important work on how thyroid status impacts the brain and behavior. Led by postdoc Dan Hochbaum who assembled quite a team urldefense.proofpoint.com/v2/url?u=https…

1.📢 Delighted to announce our new preprint on bioRxiv! "Encoding opposing valences through frequency-dependent transmitter switching in single peptidergic neurons." biorxiv.org/cgi/content/sh…

🌿 Today, we remember Salk Professor Joanne Chory, a visionary plant biologist and a force for climate action. Her research revolutionized how we understand plant biology and inspired solutions to fight climate change. Joanne’s brilliant mind and passion will forever impact the

This is very interesting work from a talented MD/PhD student in the lab. He shows the relationships between caloric depletion, AgRP neuron activity, and tail of striatum dopamine signaling in the regulation of exploration by hunger. Congrats Tarun!

Excited to share our story about a top-down slow breathing circuit just published in Nature Neuroscience! Congrats to all co-authors for their hard work, especially Jinho Jhang for his incredible contributions!! nature.com/articles/s4159…

Come read this paper!! It addresses a question that I was baffled for years and not able to solve with my PhD work: when you inhibit a *breathing* circuit, does it also reduce anxiety? Congrats, Sung, Jinho, and everyone!!!

We are looking for talented postdocs to join our team at Wu Tsai Neurosciences Institute Stanford Medicine Stanford Neurosurgery! Join us to develop single cell sequencing- and imaging-based genomic tools to understand the cell communication across space and time! Please share with anyone interested!!

Happy to share the first work from my PhD. 🔬 We show that GPCR-based norepinephrine and dopamine sensors can display crosstalk in acute brain slices and in vivo.⚡️ We hope this study will be helpful for those using these sensors and for interpreting results. 🐁

Most MIT profs who I know are extremely honest and morally upright. I hope this is an exception.

663 days since the senseless tragedy that took An, we present a manuscript that reports some of the discoveries that she left us. biorxiv.org/content/10.110…

This is something we are very excited about. Bart Lodder led this development project collaborating with Lin Tian, PhD lab. The technology makes lifetime photometry easy and, with the new dopamine sensor, allows measurements of phasic and tonic DA in vivo biorxiv.org/content/10.110…

Curious about the placebo effect, especially placebo pain relief? If so, check out our pre-print on placebo analgesia in mice bit.ly/3QlktPq, in which we ask how pain-modulatory neural circuits become activated in the brain to suppress pain in the absence of a drug. 1/9

If you like working in a lab environment but don't necessarily want to go for the PhD route - come be our lab manager! We are a pretty cool lab 😎

(1/n) Why is it so hard to stop eating when something tastes amazing? Our new Science Magazine paper reveals that dopamine helps sustain our drive for tasty treats—and may explain how anti-obesity Ozempic tames those urges doi.org/10.1126/scienc…

1/ Why do late-stage cancer patients lose motivation & sink into apathy? 🔥Our new Science paper shows cancer activates a cytokine-sensing brain circuit to lower motivation.Great work by Aelita Zhu Sarah Starosta Marco Pignatelli Tobias Janowitz &team!🧵 🔗 doi.org/10.1126/scienc…

Congrats, Shun on getting this out! We are very excited about this story which shows experience dependent plasticity of the effective sign of GABA/glutamate co-releasing synapses. The process is related to rapid experience/action outcome dependent updating of dopamine signaling

We are releasing a new tool for analyzing facial behavior called "face-rhythm". We find that its output looks a lot like motor cortical activity, and that most neural activity is related to the power but not the phase of rhythmic facial movements. github.com/RichieHakim/fa…