IZFS4Planet Zebrafish Rock! IZFS Zebrafish embryos don't need sterile dishes! Soak them overnight in a bucket of dilute bleach, air dry and reuse! Over and over #zebrafishchallenge2022 IZFS4Planet IZFS #IZFC2022

#eshg2023 tweeps: if you have patients with #ARS1 mutations, Gaurav already likely has a #zebrafish model! DM one of us for more info! @eshg2023 eshg_young

What's new with TARS2? In vitro assay and zebrafish model confirm variant pathogenicity and demonstrate certain TARS2 variants disrupt mTORC1 signaling Gaurav bit.ly/44aZnrp

Does anyone have a reporter line for investigating myelination in zebrafish and is willing to share it? #Askzebrafish #zebrafish

And all Houlden Lab posters at #ASHG23 PB4857 Rahema TRAPP genes in NDD PB4660 Rauan Kaiyrzhanov SLC4A10 in NDD PB4644 Rauan Kaiyrzhanov and Sheng-Jia Lin ACBD6 in progressive movement + NDD PB4646 @salpietro_v GTPBP1 and 2 in NDD PB4850 Kristina Zhelcheska NKX6-2 related LKD

Initiated 7 yrs ago with 89 clinicians & scientists from 72 institutes worldwide, our study on a recessive neurodegenerative disorder with complex abnormal movements in the background of neurodevelopmental phenotype due to ACBD6 deficiency is now online. UCL Queen Square Institute of Neurology UCL Brain Sciences

Thanks to extensive international data sharing, we managed to identify 45 affected individuals from 28 independent families for a novel gene-disease association. ACBD6 is a novel gene associated with dystonia and parkinsonism.MDS Aligning Science Across Parkinson’s michaeljfox.org

New paper alert! Zebrafish studies led by Sheng-Jia Lin from my lab, and collaboration with many labs around the world. Reza Maroofian Rauan Kaiyrzhanov The Neurogenetics Lab ION Barbara Vona Joseph G. Gleeson

Gratitude to our collaborators and teammates in Gaurav for their tremendous support.

I’ll be giving a seminar at Carnegie on my fav…zebrafish hair cell regeneration! 😊 Hair Cell Developmental Genetics in Zebrafish bse.carnegiescience.edu/hair-cell-deve…

Can’t believe this project was almost dead and discarded two years ago!🥹 Thanks to the reviewer’s critical comments and the team’s hard work, it has been elevated to another level and is now in Genome Medicine. Please read threads.

Publications: Müller Lab (Developmental tempo/ Deep learning/ Staging atlas) nature.com/articles/s4159… Campàs Lab Antoine Vian (Osmotic pressure/ Droplet sensors) nature.com/articles/s4146… Ishitani Lab (Dorsal organizer size/ Wnt/ NFκB) nature.com/articles/s4146…

Let’s have a weekend poll! We are getting personal 🫣 What is your biggest #zebrafish pet peeve? That is, what makes your scales crawl 😱 #RockTheVote #AskZebrafish

Thrilled to be a part of this project! Huge thanks to Thomas & Rasmus for including us in the project studying NAA80 in zebrafish. Preprint out now! #zebrafish #NAA80 Sheng-Jia Lin

I am recruiting a postdoctoral researcher to model neurodevelopmental and hearing disorders using zebrafish.

I am thrilled to share our latest work on adenine base editing (ABE) in #zebrafish led by weiqin in Nature Communications! We've engineered ABE-Ultramax, a powerful new set of editors that takes precision gene editing to the next level. OMRF nature.com/articles/s4146…

Our collaborative paper on understanding the role of DENND5A gene in brain development and its link to Developmental and Epileptic Encephalopathy (DEE) is now online in Nature Communications. nature.com/articles/s4146… Emily Banks led this project from Peter McPherson's lab

Our paper on Naa80, essential for actin N-terminal acetylation and normal hearing in zebrafish, has been selected as a cover article! life-science-alliance.org/content/7/12/e… @NAT_machinery Sheng-Jia Lin

Our paper "Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function" is now published in Nucleic Acids Res doi.org/10.1093/nar/gk…. This work was led by our super postdoc Sheng-Jia Lin * Several papers on F0 mutagenesis have been

Our five years of work is finally out! This was truly a team effort—huge thanks to the team members in Gaurav and to Gaurav for his great support! Proud of what we’ve accomplished together!