There are days in life that shake you. I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University & academic career... 1/🧵

Announcing Neo-1: the world’s most advanced atomistic foundation model, unifying structure prediction and all-atom de novo generation for the first time - to decode and design the structure of life 🧵(1/10)

New preprint: The first whole-body map of both DNA methylation and 3D genome organization at single-cell resolution across 16 human tissues, with in-depth analyses of cell type diversity of these epigenome modalities at unprecedented resolutions. (1/5)

We are proud to announce Bing Ren, PhD, as the new Scientific Director & CEO of the NYGC. Dr. Ren brings his expertise in the fields of genomics & epigenetics to the NYGC & Columbia University, where he will hold a joint appointment. For more on Dr. Ren: bit.ly/3DJXtah

Such a honor to receive 2025 MIND Prize MIND Prize. Super grateful for the recognization and support from Pershing Square Philanthropies! Pitching the idea of shortening pathological nucleotide repeats in front of board members is a thrilling experience!

This is such a cool paper and technology!! Congrats!! Great to see it in print!!

We have made too little progress on Alzheimer’s, ALS, MS and other diseases of the brain. And often the most innovative research is done by young scientists who have less access to funding. To address this funding gap, Neri Oxman, under the auspices of the Pershing Square Philanthropies

The most enigmatic structure in cell biology: the Vault. Often missing from science text books due to the mysterious nature of their existence, it has been 40 years since the discovery of these giant, half-empty structures, produced within nearly every cell, of every animals, on

In this period of uncertainty, the University will fund research that is subject to stop-work orders or the federal funding freeze, President Schill and Board of Trustees Chair Peter Barris announced today. ▶️ spr.ly/60152zZAv

Jim Carrey had it all: • Golden Globe winner • $20 million per movie • Highest-paid actor by 32 Then he said: 'Jim Carrey doesn't exist.' People said he lost it. But he actually found the truth. 9 profound lessons from Hollywood icon turned spiritual sage: 🧵

Just a few months ago, the Baker and Garcia labs released con-concurrent preprints with incredible results. They designed de novo miniproteins that bound specific peptides presented in MHC-I. Now let me show how you can use BindCraft at Ariax Bio to do the same thing.

If the structural similarity between hemoglobin and chlorophyll doesn't fascinate you, then I'm not sure we can be friends.

Can we edit the epigenome to restore youth? The surprising answer is yes. Even more surprising is when you reset a subset of DNA methylation sites, other sites are spontaneously reset too. Clearly, there's a lot of exciting biology still to uncover nature.com/articles/s4358…

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Missing this great place for science!

DNA methylation goes spatial! Introducing Spatial-DMT: a technology that co-profiles DNA methylation and transcriptome in the same tissue section. A fantastic collaboration with Wanding Zhou lab. Kudos to Chin Nien Lee Chin Nien Lee and Hongxiang Fu! biorxiv.org/content/10.110…

✨Review article from Physiology (APS Journal), DNA Methylation in Long-Term #Memory Xinyue Chen, et al. ow.ly/UNle50WTl8Y #BrainDiseases #DNAMethylation Shawn Liu

Everything you need to know about David Liu, the cofounder of $PRME and $BEAM, and the scientist behind two of the most groundbreaking gene editing technologies: prime editing and base editing. 🧬 In this thread, we’ll dive into his story, his biggest breakthroughs, and why

Today in Nature Biotechnology, we report engineered DNA recombinases with up to 53% integration efficiency and 97% genome-wide specificity at an endogenous human locus, inserting large DNA cargoes up to 12 kb for stable expression in primary human T cells, stem cells, and non-dividing

What if we could autocomplete DNA based on function? Today in nature, we share semantic design—a strategy for function-guided design with genomic language models that leverages genomic context to create de novo genes with desired functions.🧵 nature.com/articles/s4158…