Now out on Science Magazine! CryoEM active structure of MC4R and its activation mechanism uncovered. Superb work by Hadar Israeli 🦋, Oksana Degtjarik, The Shalev-Benami Lab, and all the team members! TasteLabHUJI lab contribution summarized in the video!⬇️ t.ly/uYIP

A new study between researchers from the Weizmann Institute, Queen Mary University of London and Hebrew University has uncovered the molecular switch in our #brain that controls satiety bit.ly/3uY5s9x

211 new entries this week, including this structure of MC4R, involved in appetite suppression & potential target for anti-obesity drugs. Solved: The Shalev-Benami Lab, Peter McCormick, TasteLabHUJI, Ben-Zvi lab. Published: Science Magazine. All latest entries: PDBe.org/latest

In a new paper out today in #Science, the structure of activated MC4R is revealed providing new opportunities for drug discovery as discussed in the #Perspective by Sadaf Farooqi. See our website for links to the paper and Prof Farooqi's article. goos.org.uk/resource-centr…

Don't miss this piece by Farooqi Lab on our paper describing the #cryoEM structure of MC4 receptor : ✨ Putting a brake on hunger science.sciencemag.org/content/372/65… Oksana Degtjarik The Shalev-Benami Lab TasteLabHUJI Peter McCormick Fabrizio Fierro

Nice collaboration with @LabSkiniotis and The Shalev-Benami Lab to structurally demonstrate the adhesion GPCR tethered agonist mechanism that our lab helped discover. pnas.org/doi/10.1073/pn… Eight AGPCRs in four nature papers today validate the mechanism. nature.com/articles/s4158…

日本、イスラエル、ドイツの国際共同研究の論文がNat. Struct. Mol. Biol.に公開されました。今回、藻類からロドプシンとベストロフィンが融合した、全く新しいタンパク質が発見され、その構造や光反応も報告しています。10個のロドプシンを含む超巨大複合体は圧巻です！ nature.com/articles/s4159…

Super excited to finally see this work out! A crazy team work with @BejaLab INOUE lab. (ISSP, Univ. Tokyo) Ofer Yizhar 💔 Igor Schapiro 古谷 祐詞 (FURUTANI, Yuji) and Tweeterless Hegemann, Kandori & Sheves groups. Igor Kaczmarczyk @aleph_reish Johannes Vierock and Donna Matzov, you guys did a great work! nature.com/articles/s4159…

New class of rhodopsin gated ion channels! 2 rhodopsins regulating a Bestrophin channel. Far red absorption! Alternative 11-cis isomerization! Extraordinary finding by Andrey Rozenberg and @BejaLab. Amazing structure by The Shalev-Benami Lab. Fun project and great poeple!

The craziest structure (and scientific adventure) we have had so far...

Take five bestrophin channel subunits, fuse each of them to a tandem of rhodopsins, put them all together and you get a gigantic light-driven bestrophin complex. Amazing discovery/characterization from @BejaLab The Shalev-Benami Lab INOUE lab. (ISSP, Univ. Tokyo) and many others! nature.com/articles/s4159…

Bestrhodopin are light-gated Cl channels found in dinoflagellates. They consist of 1-2 rhodopins fused w/ a Best-like channel. Given the association of Best1 patient mutants w/ eye disease, could this hint at another means of channel regulation in animals?nature.com/articles/s4159…

Exciting times at the Shalev-Benami group. Our first lab wedding (Mazal Tov Ori & Yael🎉), Our first MSc graduation (Igor Kaczmarczyk a true pleasure, congrats👨‍🎓) and Igor and Donna's paper is out NatureStructMolBiol nature.com/articles/s4159…. All in the same week! You make me a proud mama-goose!

This 3.21 Å #Rhodopsin structure resolved by #SingleParticle #CryoEM, published in NatureStructMolBiol, reports the discovery of bestrhodopsins, a microbial subfamily of the rhodopsins from a marine unicellular algae. DOI: doi.org/10.1038/s41594… EMDB: ebi.ac.uk/emdb/EMD-13485

📢Finally out! The latest work from my postdoc at the amazing The Shalev-Benami Lab Weizmann Institute is officially published today! 🎉 It was an absolute pleasure working on this project! 🔬

Thank you Weizmann Institute for a clear message. We cannot move forward before evil is clearly identified and denounced as evil.

“Today, we urge each and every one of you to stand with us against terrorism. Just as we seek truth and understanding in science, so too must we seek truth in the world we inhabit. The power of the scientific community is immense, and our voices can resonate far beyond the walls