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Dr Jennilee Davidson, a Research Fellow at the Macquarie University MND Research Centre, has been named as an international ALS Scholars in Therapeutics. Funded by FightMND, the Sean M. Healey & AMG Center for ALS at MassGeneral News and ALS Finding a Cure®. mq.edu.au/about/about-th…

Academics: “I was really struggling with this sentence, but a few hours later I got it right, then deleted it, then rewrote it, then deleted it again. Then lay down and thought about the sentence”. Parents: “your sister bought a house”.

Writing

A once in a lifetime shot ✨

🗞️ New inheritance mechanism unrelated to DNA is discovered by chance A study originally focusing on cancer has shown that amyloids influence inherited traits. The discovery could, say the authors, explain part of our ‘missing heritability’ dozz.es/m5fdk2

Eric Dane, former 'Grey's Anatomy' star, spoke out for the first time in an exclusive interview with ABC News about his degenerative neurological disorder, ALS. "I feel like maybe a couple, few more months, and I won't have my left hand (functioning) either," Dane told Sawyer,

✅ UPDATE: The crane on Pennant Hills Road at Carlingford has been recovered and all lanes of Pennant Hills Rd are open again between Marsden Rd and Evans Rd. 🚗 All diversions have been lifted, and traffic is returning to normal.

A new paper in Cell shows that it is possible (simple, really) to convert DNA-editing CRISPR proteins, such as Cas9, into RNA editors. All you have to do is delete a chunk of them. Deleting 55 amino acids from a DNA editor called IscB (the ancestor of Cas9) turned it into a

Congratulations to Selina Zhang Selina Zhang who has been awarded one of our conference scholarships to attend the Lorne Ubiquitin Conference in Australia! Read more about her and the exciting doctoral work in ALS she is doing below. #WomenInTPD

Huntington’s disease is brutal. A single DNA error → toxic protein → dead brain cells. No cure. Always fatal. Always inherited. But now? Science has flipped the script. How the new gene therapy works: 1️⃣ Huntington’s mutation makes a toxic protein that kills neurons. 2️⃣

Ah yes of course "final final version 7". That is the one!

The model of gene expression taught in school is highly misleading! Transcription factors are proteins that bind to DNA and then help repress, or activate, the expression of genes. Cells have hundreds of different types of transcription factors, each tuned to regulate different

An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier hubs.li/Q03SL_6p0 Article highlight from Cell Stem Cell

cell.com/cell/fulltext/… This is one of the best analysis of protein sequence --> function that I have seen yet!

Targeted protein degradation is a therapeutic strategy that entails hijacking a cell’s natural pathways for marking proteins for elimination. In a new #ScienceReview, researchers look at recent advances that expand the range or targets, drug modalities, and control mechanisms,

I made a Goodreads for academic papers! (..and blog posts, substacks, lesswrong, etc) Paper Trails [papertrailshq.com] is something I built because I wanted a place where engaging with research felt fun, beautiful, and personal to you I hope you give it a try & love it!

NimbusImage: a cloud computing platform for image analysis. nature.com/articles/s4159…

DISCO-seq: 3D single-cell transcriptomics of intact biological systems biorxiv.org/content/10.648… #biorxiv_sysbio