Super excited to share our work on adaptive peptide systems where we push the limits of dynamic peptide libraries (via reversible amide bond formation) to find glucose binding networks in water! @UlijnGroup Scott McPhee 🏴󠁧󠁢󠁳󠁣󠁴󠁿in🇺🇸 Naxhije Berisha CUNY ASRC J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Emergence of Cooperative Glucose-Binding Networks in Adaptive Peptide Systems @UlijnGroup CUNY ASRC The City University of New York Hunter College #Cooperative #Glucose #Binding #Networks #Adaptive #Peptide #Systems pubs.acs.org/doi/10.1021/ja…

Well done everyone!

Shingles is more common in women + ⬆️ recognition that the causes of Alzheimer’s may differ by sex (bit.ly/3HqGh8k). We find strong protective effects of the vaccine for women but none for men, and that this diff is driven by Alzheimer’s (not vascular) dementia. 11/

The systems chemistry lab will be up and running this fall @bklyncollege411 The City University of New York! We hope to work on finding systems chemistry solutions to proto-cellular life, novel therapeutics, and everything in between. For opportunities: syschemlab.com/opportunities. RT appreciated.

Happy to share that, starting this fall, I will be joining Brooklyn College The City University of New York as an asst. prof.! I will be heading Systems Chemistry Lab and look forward to working on various aspects of systems chemistry. A special thank you to @Ulijngroup, Subi George, Bert Meijer, and Praveen Kumar Vemula!

#teammassspec any suggestions on a python package to annotate an MSMS spectra using a custom fragmentation table (funky highly modified peptide)

Oh my. Time to check and revise code in structural bioinformatics...

Excellent paper describing a method for loading nanoparticles with an API with a linker that allows environment specific release. So much scope for tuning and adaption! pubs.acs.org/doi/10.1021/ac…

Cubane is similar in size to benzene and can be swapped into existing drugs to improve their properties through differences in bond angles and electronic structure. It’s just one of a range of strained bioisosteres that researchers are exploring. chemistryworld.com/features/cuban…

Want to design genetically encoded inhibitors of your favorite protein? Thrilled to announce our latest work w/ Sebastian, Keating Lab, & Gene-Wei Li Lab, where we leverage massively parallel AlphaFold predictions to discover peptide inhibitors. biorxiv.org/content/10.110… (1/n)

Chemprop: A Machine Learning Package for Chemical Property Prediction #machinelearning #compchem pubs.acs.org/doi/abs/10.102…

Ever wondered what happens when you Fourier Transform a Peacock?

Another exciting preprint from the Baker group and collaborators describing de novo design of small molecule binding proteins for application in sensors using an alternative (and complimentary) methodology to their earlier diffusion approach. #ProteinDesign

ICYMI: PDB Entries with Novel Ligands Now Distributed Only in PDBx/mmCIF and PDBML File Formats First 5-character ligand has been released: rcsb.org/ligand/A1LU6 Details: wwpdb.org/news/news?year…

Structure of a novel enzyme used everyday In laboratories around the world. It doesnt express well so structure by Xray was not possible. However, tiny amounts of material gave nanocrystals and #MicroED delivered a structure using a single nanocrystal biorxiv.org/content/10.110…

Hi! I’m a biochemistry PhD candidate at CUNY seeking a European-based postdoc position. I want to apply my structural bio skills (protein purification, NMR, MS, xtallography) to Origin of Life research. If you know of anything, please DM or email me: [email protected]

Check out my tutorial article on processing high-throughput dose-response data using a Python library I authored. Google Colab - tinyurl.com/4tn569zs link.medium.com/MSRhZ1YzvHb