🔬 Tiny crystals, big impact! Our new Nature Protocols guide helps scientists unlock the secrets of molecules using #MicroED, a powerful #cryoEM technique. We explain how to prepare samples for this cutting-edge method. #StructuralBiology #ScienceProtocols doi.org/10.1038/s41596…

#FeaturedProtocol this week from Tamir Gonen: The preparation of #microcrystals for #CryoEM enables the acquisition of diffraction patterns from nanometre-sized samples go.nature.com/4j47NcK See also accompanying News & Views

William J Nicolas Max Clabbers Mike Martynowycz Callie Saeher Anna Shiriaeva cody gillman and many others that contributed over the years to this collective #cryoem #MicroED knowledge - now at your fingertips 😍

I’m happy to share that @HWMRI has merged with UBuffalo. My lab will stay at HWI, and my title is changing. I’m starting a new position as a tenure track Assistant Professor at the Jacob’s School of Medicine at the University at Buffalo!

The 7th Challenges in Structural Biology Summit will be 9/9-12/25 at UCLAs Lake Arrowhead Resort. Brent Nannenga and I are taking nominations for speakers. Please write, self nominations are OK. Focus is on methods and challenges. Everyone speaks. Limited to 50 speakers/attendees

Happy to share high throughput ligand and inhibitor screening against enzymes using MicroED. Drug discovery based on structures Ligand Screening and Discovery using Cocktail Soaking and Automated MicroED | bioRxiv biorxiv.org/content/10.110…

Whats the best slit width for your energy filter? ⁦Max Clabbers⁩ systematically tested the settings. The results may surprise you... Characterization of energy filtering slit widths for MicroED data collection | bioRxiv biorxiv.org/content/10.110…

Probing ion channel dynamics at atomic resolution using vanishingly small crystals and #MicroED. Yes, dynamics can be probed even qith crystals... High-throughput MicroED for probing ion channel dynamics | bioRxiv biorxiv.org/content/10.110…

Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in Cell cell.com/cell/fulltext/… . What’s new?

Now most folks cant tell the difference between an Xray diffraction pattern and #MicroED 😁 Behold 0.9Å 😍

Our latest work shows how energy filtering, PFIB, and direct electron detection unlock sub-atomic resolution for #MicroED! 🎯 Great work from Max Clabbers and JohanHattne back when I was with Tamir Gonen at UCLA Biological Chemistry. Excited to bring this capability to UBuffalo!

Researchers from UCLA and UB-HWI have pushed the boundaries of electron crystallography, achieving sub-atomic resolution using energy-filtered #MicroED #CryoEM. This improves structural detail, advancing drug discovery and biomolecular research. nature.com/articles/s4146…

Super stoked that this study is finally out Heroic effort from several people and of course #cryoem #MicroED #FIB 👍👍 Structure of the lens MP20 mediated adhesive junction | Nature Communications nature.com/articles/s4146…

What holds your eye lens together? UCLA scientists along with now UB-HWI faculty found out! Using advanced microcrystal electron diffraction, they solved the structure of the abundant lens protein MP20. nature.com/articles/s4146…

Congratulations to Judge Susan Crawford on her victory, and to the people of Wisconsin for electing a judge who believes in the rule of law and protecting our freedoms.

Coming soon! Deep dish Eucharist. #Chicago #Pope

Dog is 8

🍃➡️🧬 First paper from the Martynowycz Lab! Spontaneous seed-protein nanocrystals → 0.85Å ab-initio structure of crambin by #MicroED No crystallization screens, no MR bias. Watch the diffraction-to-density movie & grab the preprint below! biorxiv.org/content/10.110…

Another fantastic results published in #JACS. This work shows a great potential of #microED for studying mineralogical and geological samples. ED data were acquired on our Glacios at CeNT UW. pubs.acs.org/doi/full/10.10…

👀 The Frontiers of Structure | Science | AAAS science.org/content/blog-p…