Science Signaling
@scisignal
Uncovering mechanisms in biology, gaining insights into physiology and disease.
ID: 137777298
https://www.science.org/journal/signaling 27-04-2010 18:46:45
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A molecular “switch” involving YAP, the exchange factor TRIO, and Rac1 and RhoA augments the migration and invasiveness of many types of healthy cells and of #glioblastoma cells, shows new work involving cells and patient data. Dr. Alfredo Quiñones-Hinojosa Johns Hopkins BME scim.ag/4dH62jA
Experiments with T cells uncover that SMAD2 undergoes #palmitoylation and interacts with STAT3 to generate proinflammatory T helper 17 cells, and that disrupting this cycle mitigates disease severity in a mouse model of multiple sclerosis. CornellChemistry scim.ag/4mEHgEE
A team of researchers has uncovered how #melanoma cells treated with a BRAF inhibitor exploit cellular structures called lamellipodia to promote their proliferation and neutralize a tumor suppressor. Tadamoto Isogai Danuser Lab UT Southwestern Medical Center scim.ag/3FmjfBA
New findings identify a molecular network that controls #CellMigration in both health and disease, correlates with poorer outcomes in patients with #glioblastoma, and could inform future efforts to constrain cell invasion in cancer. Dr. Alfredo Quiñones-Hinojosa Johns Hopkins BME scim.ag/4dH62jA
Through experiments in vitro and in mice, researchers have discovered how the protein SMAD2 promotes the development of proinflammatory T cells, which may have implications for the treatment of some autoimmune diseases. CornellChemistry scim.ag/4mEHgEE
Scientists delineate a pain perception pathway involving cyclic GMP produced by the receptor Npr2 in nociceptors and show that the receptor drives pain sensitivity and chronic pain in mice by stimulating phosphorylation of the protein CRP4. Goethe-Universität scim.ag/43sfiVm
A new study identifies a signaling axis involving the E3 ligase TRIM21 that supports metastatic growth in pancreatic cancer (#PDAC) by degrading Tap63-alpha, a transcriptional repressor of IL-20RB and an inhibitor of cell proliferation. Sichuan University scim.ag/3FJZaFu
New findings identify a molecular network that controls #CellMigration in both health and disease, correlates with poorer outcomes in patients with #glioblastoma, and could inform future efforts to constrain cell invasion in cancer. Dr. Alfredo Quiñones-Hinojosa Johns Hopkins BME scim.ag/4dH62jA
Through experiments in vitro and in mice, researchers have discovered how the protein SMAD2 promotes the development of proinflammatory T cells, which may have implications for the treatment of some autoimmune diseases. CornellChemistry scim.ag/4mEHgEE
A molecular pathway centered on a receptor named Npr2 sensitizes neurons to pain sensations in mice and could offer a potential therapeutic target in both acute and chronic pain, according to a new preclinical study. Goethe-Universität scim.ag/43sfiVm
In the new issue, researchers tie metastasis and the spread of #PancreaticCancer cells to mutations that enhance the activity of the enzyme TRIM21, a finding that could support research into new targeted therapies. Sichuan University scim.ag/3FJZaFu
Applying a new screening approach in Drosophila, scientists uncover diverse protein domains that can activate the #Notch receptor in response to mechanical forces produced by #endocytosis, which required the ADAM10 homolog Kuz. Augusta University scim.ag/4l4qzB6
A molecular pathway centered on a receptor named Npr2 sensitizes neurons to pain sensations in mice and could offer a potential therapeutic target in both acute and chronic pain, according to a new preclinical study. Goethe-Universität scim.ag/43sfiVm
Researchers recently tied metastasis and the spread of #PancreaticCancer cells to mutations that enhance the activity of the enzyme TRIM21, a finding that could support research into new targeted therapies. Sichuan University scim.ag/3FJZaFu
