New research in Science #Immunology describes how the mosquito salivary protein #Nest1 binds #CD47 for immunosuppression and encourages #Zika virus infections. scim.ag/816

New research in Science #Immunology proposes that the global spread of Omicron JN.1 variant was due to its ability to eliminate most neutralizing antibody responses. scim.ag/81T

#DOCK8-deficient B cells fail to effectively engage with and activate #Tcells in the #GerminalCenter when antigen levels are low. Learn more about this #PrimaryImmunodeficiency in Science #Immunology: scim.ag/82O

Researchers have identified a large overlap in genes causing inborn errors of #metabolism and #immunity in mice. Learn more in Science #Immunology: scim.ag/83M VUMC Pathology

A new mouse study in Science #Immunology disentangles the functions of intestinal group 3 innate lymphoid cells (#ILC3) from those of #Th17 cells in mucosal homeostasis and protection. scim.ag/84T

A new Science #Immunology study reports an overlap in #immunometabolism mechanisms underlying #Tcell function in mice. Jeff Rathmell Andrew Patterson 📄: scim.ag/85H

The presence of group 3 innate lymphoid cells (#ILC3), along with #Th17 cells, helps reduce disease severity and protect mice against high doses of infectious mucosal pathogens. Learn more in Science #Immunology: scim.ag/86j

A new Science #Immunology study suggests that #MastCells may contribute to postoperative pain in mice by releasing tetrahydrobiopterin (BH4) and serotonin. Shane JF Cronin Starkl Lab Vienna PenningerLab scim.ag/87H

Proud to share our latest paper in Science Immunology - how #mastcell -derived #BH4/#serotonin drives postoperative pain in mice, revealing a potential therapeutic target for surgical pain: scim.ag/87H Wonderful collaboration with Starkl Lab Vienna

A new Science #Immunology study finds that, like in mice, more human hematopoietic stem cells (#HSCs) become biased towards forming #platelets with age. Claus Nerlov Merve Aksöz scim.ag/889

Stoked to share the most recent paper from the lab, starring #MastCells, the probably most interesting #ImmuneCells around..at least for some people in the group (Philipp Starkl). FANTASTIC collaboration with Shane JF Cronin PenningerLab science.org/doi/10.1126/sc…

A new study in Science #Immunology describes a #PPARβ/δ-mediated metabolic switch that may promote memory #Tcell longevity in mice. scim.ag/890

Researchers have identified substance P-induced mast cell activation as a driver of pain after #surgery in mice. Shane JF Cronin Starkl Lab Vienna PenningerLab Learn more in Science #Immunology: scim.ag/89P

New in Science Immunology: Researchers find that some bone marrow hematopoietic stem cells (#HSCs) in humans are fated to become platelets, and these #plateletbiased HSCs become more common with age. scim.ag/8aE MRC WIMM

New research from the HoLab suggests that activation of the transcription factor PPARβ/δ is necessary for central memory #Tcell formation in mice. Learn more in Science #Immunology: scim.ag/8bB

Two new studies in Science #Immunology highlight GT1.1, an HIV immunogen that induces broadly neutralizing antibodies in non-human primates, advancing #HIV vaccine efforts. 📄: scim.ag/8cE Tom Caniels 📄: scim.ag/8cD Ashley Nelson, PhD

A new Science #Immunology study in adult rhesus macaques describes GT1.1, an immunogen that can activate B cells to produce broadly neutralizing #antibodies against the #HIV CD40-binding site. Tom Caniels Amsterdam UMC scim.ag/8e4

New research reports that, in response to immunogen stimulation, infant macaques can generate early neutralizing #antibody responses against #HIV, comparable to those in adults. scim.ag/8eW Sallie Permar MD PhD

New studies from two teams report promising results in #HIV vaccine development, showing that the HIV immunogen GT1.1 can prime B cells in monkeys to produce #neutralizingantibodies targeting the viral envelope. 📄: scim.ag/8g1 📄: scim.ag/8g0