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We're thrilled to share that Savvas Savvides Lab's mechanistic and #structural studies on newly described #trimerization of #Leptin receptor has been published NatureStructMolBiol today! Many congrats to everyone contributing to this work! VIB nature.com/articles/s4159…

Given ISOLDE is a model-fitting tool, it was about time I gave it a way to, you know, actually validate the fit of a model to a map. As such, in consultation with Greg Pintille and Tom Goddard I've implemented the Q-Score algorithm (nature.com/articles/s4159…) in ChimeraX. (1/2)

Check out the latest issue of NatureStructMolBiol featuring Tsirigotaki et al. nature.com/articles/s4159… on the Leptin-mediated receptor complex as a cover story and additional coverage via a News & Views article nature.com/articles/s4159…

Big thanks to Synchrotron SOLEIL & Proxima2-A for giving our UGent students a memorable visit and an on-site view into both theory & practice in #proteincrystallography! #structuralbiology @LM_UGent

We are heading with a team of seven to Athens, Greece for a very exciting #cytokines2023

Great start to an inspirational #cytokines2023 at the foot of the Acropolis ICIS 🦋 @cytokinesociety.bsky.social

Ex vivo X-ray crystallography meets Immunology inside and outside the box in our latest collaborative work with bart lambrecht and colleagues at the IRC - VIB/UGent and UGent doi.org/10.7554/eLife.…

We just had a very exciting, educational, and interactive symposium on #AI in #StructuralBiology hosted by VSC | Vlaams Supercomputer Centrum and FWO…Prediction cannot happen without experiments! #AlphaFold #StructurePrediction #XrayCrystallograpy #CryoEM

Continuing the brainstorming session at a #Brussels institution #MortSubite

HAPPY 30th BIRTHDAY TO US🎂 First issue of NSMB came out in January 1994. Come celebrate with us 30 years of changes and progress in structural and molecular biology nature.com/nsmb/volumes/3… We are continuing celebrations throughout the year with more content, so stay tuned!

Delighted to share our work in NatureStructMolBiol on #structures of IL-12/23 cytokine complexes involving the complete extracellular domains of IL-12 family receptors, jointly celebrating 30 years of IL-12 receptor #immunology and NatureStructMolBiol nature.com/articles/s4159…

Marie Skłodowska-Curie Actions @GoossensLabVIB Bart Ghesquière jenny russinova Frank Van Breusegem Lab MarineLab RaesLab @jeroenraes @FarrowLab Agostinis Lab Verstreken Lab @VanderhaeghenP2 MINDlab @FendtLab Savvas Savvides Lab @steinaerts Martin Toul Avilien Dard Yongming Luo Kresimir Sola @M4riekeHoekstra Célia Lentini

Training the next generations of scientists in experimental structural biology. We are grateful to Synchrotron SOLEIL and Proxima2-A for hosting our Master program in Biochemistry-Biotechnology UGent for a practical workshop on X-ray crystallography.

biorxiv.org/content/10.110… A prodigious effort and interdisciplinary collaborative work by Switch Lab at VIB KU Leuven , serranoLab at Centre for Genomic Regulation (CRG), Savvas Savvides Lab at VIB IRC - VIB/UGent UGent, and Maarten Dewilde Lab KU Leuven

Read the preprint bit.ly/3QpiUk1 describing a milestone in our de novo antibody design efforts. Our pipeline can now design high-affinity and stable antibodies in a single round! Fantastic collaboration with serranoLab Savvas Savvides Lab & Maarten Dewilde KU Leuven

Happy to share the #preprint on #denovo #antibody design in a single round yielding stable Abs with high affinity: lnkd.in/ew5ATYHy Grateful to be part of great collaboration efforts betwen Switch Lab KU Leuven Centre for Genomic Regulation (CRG) IRC - VIB/UGent VIB UGent

Improved protein binder design using beta-pairing targeted RFdiffusion 🚀 New preprint from David Baker!🚀 • A breakthrough in protein binder design: this study uses RFdiffusion conditioned to generate binders that form precise beta-strand pairings with polar protein targets,

Please follow us on Bluesky 🦋 @savvideslab.bsky.social