Many bacteria have >1 CRISPR system, and they affect each other! Shally Margolis found a 3-way interaction that leads to primed adaptation in the RNA-targeting type VI system, check it out:

More wonderful #ASBMBMemberMonday updates: ⭐CUR honors Shubhik DebBurman with a mentoring award. ⭐Anush Margaryan wins a Projects for Peace grant to teach refugees in Armenia. ⭐Penn names Andrew Santiago-Frangos, PhD an endowed assistant professor. asbmb.org/asbmb-today/pe…

🚨New preprint from our lab! We map the RNA interactions in E. coli infected by lambda, revealing an RNA-driven regulatory layer in phage-host dynamics. We find a phage-encoded sRNA hijacking host replication machinery, impacting the phage cycle.#microbiology #phages Regulating with RNAs in Bacteria and Archaea

Excited to be going to ABRCMS this year! Looking forward to meeting new (and old) friends and sharing work! :D

Incredibly cool work from my former colleagues Kaitlyn Kiernan David Taylor visualizing Cas9 turnover: 25 structural states from a single kinetics-guided cryo-EM dataset 👀 biorxiv.org/content/10.110…

Reliable amplification of highly repetitive or low complexity sequence DNA enabled by superhelicase-mediated isothermal amplification biorxiv.org/content/10.110…

I’m excited to share our latest study led by Giulia Pasquesi out today in Cell Press , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵

Can LLM agents discover novel protein functions? Introducing Gaia Agent 🌎 🤖: an AI biologist capable of reasoning across genomic contexts to predict functions of proteins! Gaia Agent is now integrated with Gaia Search at gaia.tatta.bio

OUT NOW: Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons Sternberg Lab MDMLab Hugo Vaysset nature.com/articles/s4156…

Finally posted - our structures that explain directionality control in large serine integrases! Read all about how these amazingly clever molecular swivels are controlled: biorxiv.org/content/10.110… Great work by postdoc Heewhan Shin and many thanks to collaborator Femi Olorunniji.

Congrats to Sumanth Mutte Patrick Barendse and Pilar B U - it is amazing how a "simple" question can turn into an entirely new project with exciting insights!

Meet one of our speakers: Nicole Marino who is an assistant professor at UPenn. Nicole's research interests lie in interplay between bacterial defence against phage infection and how phage evade those defences. 🧫🦠 ⚔️#CRISPR2025

🚨Paper in Press🚨 Our latest biophysical study of oleate hydratase binding the #membranebilayer is out!🔬#lipids #phosphorusNMR #spectroscopy #FluorescenceCorrelation #microscopy #singlemolecule #hybridtechniques University of Kentucky College of Medicine UK Microbiology Immunology & Molecular Genetics University of Kentucky College of Pharmacy frontiersin.org/journals/molec…

Really excited to visit Molecular Microbiology and Immunology at JHSPH and share some of our unpublished findings about the noncanonical inflammasomes!

Thrilled to share our published eLife - the journal paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. Dr. Marisa Egan (CAMB Graduate Group alum, now an Assistant Professor at Swarthmore College Biology)! 🧵(1/n) elifesciences.org/articles/90107

New cryo-EM structures shine light on key steps in CRISPR-based adaptive immunity! Viral DNA induces a structural change in the Cas1-2/3 integrase needed for recruitment to the CRISPR. We capture how CRISPR repeat is unwound to allow complete integration! biorxiv.org/content/10.110…

🚨 new paper alert! science.org/doi/10.1126/sc… During my PhD, one of the most frustrating challenges was trying to interpret genes labeled as “hypothetical proteins.” 1/n

This work is now published with Science Advances with some new and exciting results. Please check out: science.org/doi/10.1126/sc…