Advances in bioengineering and organic chemistry have enabled targeting of the previously ‘undruggable’ #KRAS ; our latest review from Eileen M O’Reilly & colleagues discusses the successes, challenges & future of KRAS therapeutics in #cancer
Memorial Sloan Kettering Cancer Center
nature.com/articles/s4159…

#OpenAccess in Nature Medicine
Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning
nature.com/articles/s4159…
Fantastic study that uses tens of thousands of cytology cases for training & test sets for assessing CUP patients.

📢 Looking for your next conference after #AACR24 ? Check out our upcoming Nature Conferences on #cancer #immunotherapy ! Planned w/ Nature Rev Immunol Nature Cancer Nature Immunology
🗓️ Abstract & Early Registration Deadline = THIS Fri, April 12th
🎟️More details here: go.nature.com/CancerImm

In children with refractory cancer, ex vivo testing of tumor cells for drug sensitivity and genomic profiling guided successful therapy ('functional precision medicine') for some
nature.com/articles/s4159…
Nature Medicine

New data show that ex vivo drug screening of pediatric #cancer samples can identify effective therapies. If validated, this could herald a new approach to #precisiononcology
News & Views from Emmy Dolman, Paul Ekert Peter Mac Cancer Centre Childrens Cancer Institute
nature.com/articles/s4159…

Check out this trial led by #AACR24 Clinical Trials plenary session speaker Timothy Yap: an oral ATR inhibitor was well tolerated & exhibited anti-tumor activity in DDR-deficient solid tumors, particularly in patients with #OvarianCancer nature.com/articles/s4159…

#1/8 Multicenter P1/2 trial of a personalized neoantigen vaccine + anti-PD1 (pembro) in 2L #HCC presented at #AACR2024 & published in Nature Medicine
➡️nature.com/articles/s4159…
ORR 31%,⏫historical control of pembro monotherapy (~17%)
Details below:

At the #CancerVaccines #AACR24 session? Check out this recent trial led by Dr. Shubham Pant Eileen M O’Reilly Elicio Therapeutics reporting results of a lymph node-targeting mutant #KRAS peptide vaccine given to patients with #PancreaticCancer and #ColorectalCancer nature.com/articles/s4159…

Attending the clinical trials #AACR24 plenary session on novel #immunotherapy strategies? Check out this phase 1/2 trial of an #OncolyticVirus + anti-PD-1 in patients with recurrent #glioblastoma . Work led by Farshad Nassiri gelareh-zadeh nature.com/articles/s4159…

NEW online & being presented this afternoon at the #AACR24 poster session: A personalised DNA #CancerVaccine + anti-PD1 was safe & led to encouraging clinical efficacy in patients with advanced #LiverCancer Mark Yarchoan Johns Hopkins Kimmel Cancer Center Niranjan Sardesai #HCC nature.com/articles/s4159…

Outstanding talk by Jakob Nikolas Kather at the #AACR24 Opening Plenary Session, providing an overview of #AI advances in #digitalpathology reaching clinical oncology.

Also very proud to see Nature Medicine pioneering impactful studies in this field and staying at the forefront of innovation

Check out this study from #AACR24 opening plenary speaker Jakob Nikolas Kather: a decentralized, privacy-preserving ML framework used to train an #AI system identifies actionable molecular changes in patients with #ColorectalCancer with routine #histopathology data nature.com/articles/s4159…

At the #AACR24 #CellTherapies in solid tumors session? Check out our 2 recent trials on #CARTcells in patients with #glioblastoma !
Work led by Christine Brown City of Hope: nature.com/articles/s4159…
Work led by Stephen Bagley DrORourke Penn Medicine: nature.com/articles/s4159…

This piece in STAT is a must read. Pediatricians (and pediatric subspecialties) deserve more support, including better pay. Lots of great points made here. Kids' lives should matter more than they currently do in the US. statnews.com/2024/04/02/too…

Easter paper of the month with Matt Galsky - gem/cis/nivo with bladder sparing approaches and single agent nivo in responders. Magic data. Move to a cystectomy free era I hope . Nature Medicine podcasters.spotify.com/pod/show/the-u…

Promoting gender equity in the scientific and health workforce is essential to improve women’s health.

Comment from Cristiani Vieira Machado and colleagues Editora Fiocruz Fiocruz, as part of our series on women's health.

nature.com/articles/s4159…

Immune checkpoint blockade plus a vaccine including self-amplifying mRNA-encoded neoantigens derived from common oncogenic driver mutations was safe and elicited neoantigen-specific T cell responses in patients with advanced solid tumors #CancerVaccine
nature.com/articles/s4159…

Twitter fam! We are looking for a research associate to join our awesome team. If you know anyone interested in the interface of protein engineering, structural bio, gene editing and T cell immunotherapy please reach out! Also, please retweet and spread the word!