Happy to share an update to our TCR structure database, TCR3d, now online at Nucleic Acids Res! More structures of TCR complexes, as well as TCR mimic antibodies, pep-MHC complexes, tools, and affinities. IBBR UMD CBMG #tcell academic.oup.com/nar/advance-ar… tcr3d.ibbr.umd.edu

The fabulous Norbert Pardi and I wrote a review about mRNA vaccines for infectious diseases. Maybe worth a read if you are interested in the topic. nature.com/articles/s4157…

These laureates are VERY deserving. But an important addendum—no model could be trained without 40 years of Helen Berman and others’ work at the PDB, and we would not be certain of AF’s success without 30 years of John Moult and others’ work on CASP. Hats off to them as well 🥂

Yesterday a Nobel prize was given for alpha fold. Alpha fold could not exist without the Protein Data Bank (PDB), a public database funded by US taxpayers. Every structural biologist in the world that deposited their structure to the PDB indirectly helped train alpha fold.

New work on protein design... 🚨S2 immunogen design using advanced simulation WESTPA Software WE MD--> opening mechanism--> design--> stabilized protein--> cryoEM structure + immunology Xandra Nuqui Lorenzo Casalino Jason McLellan Kartik Chandran nature.com/articles/s4146…

Happy Birthday PDB, announced #OTD in 1971 In Nature New Biology. Today we celebrate the 53rd anniversary of the Protein Data Bank and the PDB depositor community, and congratulate the 2024 Nobel Prize in Chemistry Awardees rcsb.org/news/feature/6…

Timescales in Cell Biology

IBBR's annual pumpkin carving contest did not disappoint! We had everything from Pacman to geese to virtual pumpkins! And the first place winner went to the Pandas! We are so excited to meet Bao Li and Qing Bao National Zoo in the new year!