Some questions that come up frequently at renal clinic re advanced CKD patients: 1. Is there a GFR level below which you don’t start ACEI/ARBs? 2. Is there a GFR level below which you stop thiazides? @askrenal

Kazem Fallahzadeh, MD, MAS @askrenal We do not yet know whether stopping RAAS blockade in stage 4 or 5 CKD improves outcomes ... await STOP-ACEi Trial findings 📌 This is one of the controversies raised during #KDIGOBPinCKD 🇬🇧 #Nephpearls #AskRenal 👉🏼 kdigo.org/wp-content/upl…

Interesting thread - Questions around ACEi/ARB use in advanced CKD remain unresolved and relevant for clinical care. We hope to provide some answers with #STOPACEi trial. Patient recruitment now complete. Results expected in 2022.

We're working on it! All participants now recruited. Follow-up ongoing. Results expected in 2022.

The latest #STOPACEi newsletter is now available to read birmingham.ac.uk/research/activ…

We do not yet know whether stopping RAAS blockade in stage 4 or 5 CKD improves outcomes ... await STOP-ACEi Trial findings 📌 This was one of the controversies raised during KDIGO #KDIGOBPinCKD 🇬🇧 meeting #Nephpearls #NephJC 👉🏼 kdigo.org/wp-content/upl…

Controversy: Preliminary data from a RCT on uselfness of ACEi on progression of CKD in patients without diabetes and no proteinuria. Author of this study (ongoing) mention AJKD & STOP-ACEi Trial #SENefro18

The December #STOPACEi newsletter is now available to read birmingham.ac.uk/research/activ…

Javi Rodriguez We do not yet know whether stopping RAAS blockade in stage 4 or 5 CKD improves outcomes ... await STOP-ACEi Trial findings 📌 This was one of the controversies raised during KDIGO #KDIGOBPinCKD 🇬🇧 meeting #Nephpearls #NephJC 👉🏼 kdigo.org/wp-content/upl…

The latest #STOPACEi Newsletter is now online birmingham.ac.uk/research/activ…

Standing room only at pop up session 2 - optimising recruitment to renal RCTs QuinteT Leila Rooshenas #UKKW2019

Joseph Vassalotti, MD We do not yet know whether stopping RAAS blockade in stage 4 or 5 CKD improves outcomes ... await STOP-ACEi Trial findings 📌 This was one of the controversies raised during KDIGO #KDIGOBPinCKD 🇬🇧 meeting #Nephpearls 👉🏼 kdigo.org/wp-content/upl…

We do not yet know whether stopping RAAS blockade in stage 4 or 5 CKD improves outcomes ... await STOP-ACEi Trial findings 📌 One of the controversies raised during #KDIGOBPinCKD 🇬🇧 meeting #Nephpearls 👉🏼 kdigo.org/wp-content/upl…

Currently, there is uncertainty as to whether the potential improvements in mortality & morbidity brought about by delaying ESKD and dialysis conferred by cessation of ACEi/ ARB off-set any increase in CVD by their omission #Nephpearls 👉🏼 karger.com/Article/Pdf/44…

More and more observations regarding benefits of RAASi in advanced CKD, awaiting the one RCT STOP-ACEi Trial for confirmation! JAMA Internal Medicine jamanetwork.com/journals/jamai…

When do you hold ACEi? When do you restart? Thanks for disentangling this problem! A must read for persons who work to prevent ESRD. Should Renin-Angiotensin System Blockade Be Avoided in Patients With Declining Kidney Function? ajkd.org/article/S0272-…

Holly Kramer, MD, MPH Thanks for posting. Real struggle to disentangle clinician gestalt as a confounder when interpreting these outcomes you’d suspect? Everyone looking forward to results of STOP-ACEi Trial for RCT evidence.

LaurieTomlinson STOP-ACEi Trial I wish I had the answer but hopefully soon, probably next year

David Collister @petermagner2 Juan Carlos Q Velez Ayman Al Jurdi, MD FASN Nice one I am looking forward to the STOP-ACEi Trial as well

New paper out in JASN_News! We compared stopping versus continuing renin-angiotensin system inhibitors (ACEi or ARB) in patients with advanced CKD on the risks of death, MACE and KRT Juan Jesus Carrero LaurieTomlinson Catherine Clase jasn.asnjournals.org/content/early/…