Professor Hongkui Deng’s team and colleagues elucidated the underlying mechanisms of functional maturation of stem cell-derived β cells. #PKUResearch cell.com/cell-stem-cell…

Zhang and colleagues report a social-vector code in which the position of conspecifics is represented relative to self-position in the hippocampus of female mice. #PKUResearch nature.com/articles/s4146…

Prof. Du Peng's team at Peking University discovered two types of human totipotent cells, shedding light on early human development. Details in Cell. #PKUResearch doi.org/10.1016/j.cell…

Dr. Zhe Zhang’s team provides structural insights into VAChT neurotransmitter recognition and inhibition. #PKUResearch nature.com/articles/s4142…

By analyzing eDNA from Tibetan Plateau lakes, researchers discovered biodiversity ranging from microbes to large mammals and unveiled the ecological networks. #PKUResearch doi.org/10.1016/j.isci…

A DGCR8/FLII/JUN-mediated transient transcriptional activation governing embryonic morphogenesis and pluripotency transition during implantation. #PKUResearch cell.com/molecular-cell…

Dr. Di Zhang and collaborators uncovers L-lactylation of lysine as the predominant lactylation isomer in cellular histones, which dynamically responds to glycolysis and correlates positively with lactyl-CoA levels. #PKUResearch nature.com/articles/s4158…

Mrc1/CLASPIN binds H3-H4 tetramer, transfers parental histones to both daughter strands at replication fork, and aids heterochromatin inheritance. #PKUResearch doi.org/10.1016/j.cell…

TBEs achieve thymine editing through engineered UNG, representing efficient, specific and low-toxicity approach with potential applications in therapy. #PKUResearch nature.com/articles/s4146…

This study used calcium imaging to collected a big data of V4 responses to 20K natural images and revealed the functional organization for natural image encoding. #PKUResearch nature.com/articles/s4146…

Dr. Junyu Xiao's group has unveiled the intricate structure of the high-affinity IgE receptor FcεRI complex. FcεRI is found on mast cells and basophils, and plays a crucial role in IgE-mediated allergic responses. #PKUResearch nature.com/articles/s4158…

Dr. Ying Zhang and collaborators found that early tumor editing preferentially suppresses innate immune signaling to reduce tumor immunogenicity, which can be reversed by inhibiting DNA methylation. #PKUResearch nature.com/articles/s4159…

Proteasomes regulate stress granules (SG) dynamics and confer plant heat stress resistance by promoting SG clearance without affecting SG components’ mobility. #PKUResearch cell.com/molecular-cell…

The identified functional map of serine, threonine and tyrosine residues is highly relevant to phosphorylation, structural maintenance and clinical significance. #PKUResearch nature.com/articles/s4158…

Reversal of diabetes in a T1D patient using chemically-induced pluripotent stem cell-derived islets and a novel transplantation strategy. #PKUResearch cell.com/cell/fulltext/…

Research from Junyu Xiao's lab unveils the cryo-EM structure of human IgM with CD5L! They show that CD5L reduces IgM's binding to pIgR while preserving FcμR binding and complement activation. An updated perspective on circulating IgM! #PKUResearch nature.com/articles/s4146…

Prof. Xiaofeng Zheng's Team Unveils a Mechanism of Drug Resistance in ENKTL Patients: The USP1-ATF4-CD98hc Axis Enhances ENKTL Drug Resistance via Tumor-Derived Extracellular Vesicles. #PKUResearch science.org/doi/10.1126/sc…

Wang et al. reveal PLIN2 as a promising therapeutic target for MASLD, showing that GalNAc-siPLIN2 reduces liver fat and improves liver health in mouse models. #PKUResearch sciencedirect.com/science/articl…

Gao et al. reveal that Ehbp1 plays an evolutionarily conserved role in directing Wnt sorting to basolateral and apical membranes, essential for precise signaling. #PKUResearch embopress.org/doi/full/10.10…

Deng and colleagues used small molecules to dedifferentiate human adult cells into fetal-like progenitors. These cells, similar to embryonic limb-bud progenitors, showed enhanced expansion and osteochondrogenic potential, offering a platform for generating functional cells.