Just shared at Keystone Symposia a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts

1 in 8 women in the US will receive a breast cancer diagnosis in their life. Arc Investigator Hani Goodarzi led a TED Talks session on applying advanced AI and novel RNA molecules to detect+track breast cancer – changing the future of how cancer is screened bit.ly/3HCZpzx

Excited to share this new work from Arc Institute-- led by graduate student Sita Chandrasekaran and undergrad Cyrus Tau with Patrick Hsu. Building on our previous work on Cas13d-based RNA targeting we can now write full sequences into endogenous RNA!

Great to see Cas13d working so well for multiplexed RNA targeting in T-cells!

In some new work (the first from the new lab!), we lay out a vision for a biological foundation model that unites DNA, RNA, and protein modalities and operates at molecular, systems, and genome levels of scale. Blog: arcinstitute.org/news/blog/evo Preprint: arcinstitute.org/manuscripts/Evo

Thank you to Patrick Hsu, Silvana Konermann, Gideon Yu and Afton Vechery for sharing your insight and inspiration at the #RegenronISEF Opening Ceremony!

Grateful to announce the opening of my lab at the Arc Institute as an Arc Science Fellow! My interdisciplinary team will demystify the role of anti-aging metabolites in aging and age-related diseases for the development of ‘metabolite-inspired’ treatments.

A #ProudMentor moment; my first graduate student, Uche Medoh, is opening his own lab at the Arc Institute as an Arc Science Fellow! I cannot wait to see all the great discoveries he will make. Apply to his lab if you are looking for a postdoc position. Congrats, Uche!🚀

Excited to join Arc Institute and work on bringing this virtual cell vision to life! We’re hiring in my group as we scale up both data generation and compute 🚀 Stay tuned for more details, and DM/email me if interested.

🎧 Exciting new discovery from Lingyin Li and postdoctoral researcher Chris Ritchie on PELI2: a protein that functions like noise-canceling headphones for the cGAS-STING pathway. cGAS-STING is a crucial immune defense mechanism for the human body that’s triggered in response to

A new chapter for genome editing: RNA-guided recombinase enzymes have been discovered that enable the programmable insertion, inversion or deletion of long DNA sequences go.nature.com/3RHgWMA

🧬 Turns out, mRNA isn't just a passive genetic courier. Arc’s Goodarzi lab, in collaboration with LukeGilbert’s lab, discovered that mRNA can actively control its own expression using newly discovered "RNA switches." The team found over 200 of these switches in human cells,

An exciting update from Arc! Today, we launched our Scientific Advisory board and welcomed our first Scientific Advisors, Nobel Laureate Dr. Carolyn Bertozzi and Dr. Aviv Regev, EVP of Genentech Research & Early Development. Both Drs. Bertozzi and Regev have long careers

Honored to participate in the Arc Institute mission as a member of the SAB 🙏