Do you struggle to keep up with the organic synthesis literature? Our former postdoc Steven Bennett has started the Organic Synthesis Newsletter, a fantastic weekly summary of the recent literature. I highly recommend you subscribe for this FREE resource!!

organicsynthesis.beehiiv.com

Interested in the origins of stereoretentive enantioconvergence? Francois Richard and I have just written a 'Behind the Paper' post where we explain all - starting from Andy Lawrence's 2012 (!) total synthesis of rac-incarvilleatone.
tinyurl.com/3nxzjk76

#OrganicChemistry

A New Synthesis of Beraprost
youtu.be/y18_c7aYxm4

The serendipitous discovery of a t-BuLi mediated dehalogenation-aromatization reaction enabled the total synthesis of Beraprost and set the stage for a unique approach to the modular synthesis of indolines. Congrats to the team who put so much into the project Steven Bennett

Great to see this out in J. Am. Chem. Soc.! The serendipitous discovery of a t-BuLi mediated dehalogenation-aromatization reaction really facilitated the total synthesis of Beraprost and set the stage for a unique approach to the modular synthesis of indolines.

Check out our new pre-print that shows you don’t need labile stereogenic units to achieve stereoconvergency! doi.org/10.26434/chemr… Stereoretentive-enantioconvergent reactions represent a new approach to #AsymmetricSynthesis .

#Chiral #Catalysis #Enantioconvergent

I had a great experience working with Andy and his group - the depth of knowledge and quality of chemistry there is incredible and I can’t recommend them enough.

I look forward to seeing what comes out of the group in the future and starting a new career BioAscent!

Thank you for validating a cool procedure for aldol and dimerisation of succinaldehyde in very high ee. Very useful for prostaglandin synthesis and other 5-ring carbocycles. Dirk H. Trauner Synthesis@Bristol Organic synthesis

Our paper on the enantioselective allylic alkylation of 4-members sulfones is out in J Org Chem/Org Lett just in time for Christmas.😅 Many congratulations to Gillian! 👏✊🎉 pubs.acs.org/doi/10.1021/ac…

Sheenagh Aiken After a short break we have accumulated a number of topics to share. This time it's former PhD/post-doc Steven Bennett summarising the effect of quantum mechanical tunnelling in chemical reactions: