Ruffell Lab
@ruffell_lab
Cancer immunology lab @MoffittResearch investigating the role of dendritic cells and macrophages in breast and prostate cancer.
ID: 1374785509902409735
https://labpages2.moffitt.org/ruffell/ 24-03-2021 18:10:24
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Our review on a topic we eagerly enjoy exploring in the lab- how our fav immune cell types influence/are influenced by metabolic disorders preceding cancer- so much to learn! 👏🏻👏🏻 to #DanielTaranto for leading the effort, to Daan J. Kloosterman and the whole lab for their input! 🔥🔥
Congratulations Dr. Liu Siteman Cancer Center and collaborators Beatty Lab and K.Bryant on their featured article in Science Translational Medicine . And HUDGE THANKS to PanCAN for bringing this team together and funding the trial that came out of the science with @verastemoncology.
People, the IL-1 pathway is SO RELEVANT in cancer 🔥🔥 IL-1a released from dying tumor cells dampens anti-tumor immunity by recruiting immune suppressive myeloid cells - this limits efficacy of chemo and ICB by Brian Ruffel in Cancer Cell cell.com/cancer-cell/fu…
Excited to share our latest by Triantafyllia where we find that IFNg acts as a metabolic switch to prune tumor-associated lymphangiogenesis and unlink immune surveillance and metastasis biorxiv.org/content/10.110… #theLundLab
#ScienceSaturday ➡️ Did you know that some chemotherapies can enhance the immune response against #cancer? ❓ How might we potentiate this? ➡️ Ruffell Lab and colleagues from Moffitt Cancer Center found that the necrotic cell death induced by #chemotherapy releases IL-1 alpha
