New year, new manuscript! Our work on mapping transport between the nucleus and the cytoplasm is now on BioRxiv, and it's time to embark on a journey through the nuclear pore complex. Nuclear what? Bear with me! biorxiv.org/content/10.110…

Check out this great work led by Barak Raveh, a first of its kind, integrative spatiotemporal map of the NPC explains the main molecular mechanisms underlying nuclear transport! A NCDIR @IntActOme special with our friends Andrej Sali lab, David Cowburn and Elizabeth Villa

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Biomedical PhD with no more than 24 months of postdoc experience? Interested in learning more about the HHMI Hanna H. Gray Fellows program? $1.5M award that bridges postdoc to early career faculty Join us for an informational webinar Monday 1/22/2024 3:30pm. Registration

Excited to share my final PostDoc work! Introducing MagIC-cryo-EM🪄 & DuSTER🧹, these methods reduce cryo-EM sample requirements (0.0005 mg/mL), enabling ALL biologists to explore the structural basis of diverse biological events! BioRxiv: biorxiv.org/content/10.110…

Did you ever wondered how "jumping genes" actually jump? 2 papers now published in nature show the 3D structure of the enzyme responsible for human LINE-1 retrotransposon (links 👇). Congrats to the authors ! A Nature News & Views to recap the many new insights nature.com/articles/d4158…

First paper: nature.com/articles/s4158… by Marty Taylor, MD PhD @macro_momo ROME Therapeutics Benjamin D. Greenbaum Rout Lab Kathleen Helen Burns and many others not on X.

.yael udi et al. Rout Lab present a new method for quantitative subcellular fractionation of a wide range of mammalian cells while maintaining nuclear integrity. hubs.la/Q02jSHrM0 In our Tools collection: hubs.la/Q02jSK0L0

Dynamin-like proteins at the nuclear envelope? That and other surprises in excellent work by Philip Mannino with help from Nick Ader Melia Lab and @LuskingL! #autophagy biorxiv.org/content/10.110…

Postdocs! Apply now for the Exceptional Scholars Workshop, a program for mentorship of postdoctoral fellows from underrepresented or disadvantaged groups as they enter prepare for the faculty search and interview process. More info here: ruscholars.rockefeller.edu

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Rockefeller's Sanford Simon featured in The Guardian for his work on fibrolamellar carcinoma, a rare liver cancer: “The moment I learned of Elana’s condition is seared into my memory. I was determined to find out what caused it and find ways to counter it." theguardian.com/science/2024/m…

It cannot be done, they said.. It's too flexible, they said.. 😁 biorxiv.org/content/10.110… #NPC #teamtomo #integrativemodeling by Digvijay Singh Neelesh Soni Josh Hutchings Ignacia Echeverria et al. Great collaboration w/ Qiang Guo, Brian Chait, Javi Fernandez-Mtnz, Rout Lab Andrej Sali lab

Wow! Elizabeth Villa Digvijay Singh Andrej Sali lab

In a great collaboration with Hummer Lab and the Kräusslich lab, Jan Philipp Kreysing, Maziar Heidari, Vojtech Zila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (Max Planck Institute of Biophysics CIID_Heidelberg).

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From preprint to journal. Our nuclear gatekeepers have successfully unlocked the gates to Cell (Journal) cell.com/action/showPdf… #NPC #integrativemodeling Congrats to team Digvijay Singh Josh Hutchings Ignacia Echeverria Rout Lab Andrej Sali lab Elizabeth Villa Animation youtube.com/watch?v=LiKdFI…

Amazing! Congrats Steve

Congratulations all authors, particularly Digvijay Singh Neelesh Soni Josh Hutchings who led this heroic effort on the first molecular model of the NPC nuclear basket. Out now in Cell