The NIH has awarded Jennifer Kong of the Rohatgi Lab the K99/R99 Pathway to Independence Award! This award aims to help outstanding postdoctoral researchers complete training and transition to independent, tenure-track or equivalent faculty positions. Congratulations, Jenn!

A review from our own Jenn Kong on biochemical mechanisms of Hedgehog signaling, written with Christian Siebold, is out in Development-- includes an analysis of the many patched and smoothened structures. Development dev.biologists.org/content/146/10…

We welcome feedback on bioRxiv in collaboration with Radhakrishnan lab: sphingomyelin and accessible cholesterol regulate Hedgehog signaling at primary cilia #gpcr #cilia #lipids #signaling #developmentalbiology #crispr biorxiv.org/content/10.110…

Nice collaboration with the Siebold lab reveals the deep evolutionary connection between Hedgehog signaling and cholesterol transport-- congratulations to Maia Kinnebrew. Cholesterol is both a substrate and (when coupled to a protein ligand) an inhibitor of Patched!

Shorter title, new in vitro data, updated single-cell splicing reporter (available Addgene): our work on TDP43 phase separation and splicing function is now online! nature.com/articles/s4146… Rohatgi Lab Stanford Biochemistry

Broder's new paper presents a rigorous approach to test the connection between phase separation and function. Distinguished by the use of compositional mutagenesis to tune phase properties linked to hard biochemical readouts. nature.com/articles/s4146…

Membrane cholesterol accessibility as the messenger that communicates the hedgehog signal between patched and smoothened. Collaborative work with Arun Radhakrishnan's lab: elifesciences.org/articles/50051 #gpcr #cilia #lipids #signaling #developmentalbiology #crispr

Congrats to Ramin Dubey on his work linking lipid droplets to hydrophobic drug activation: nature.com/articles/s4158…. We are grateful to our our collaborators and to James Olzmann for their News and Views on "enzymatically regulated phase partitioning": nature.com/articles/s4158…

Check out this article by Ramin Dubey of the Rohatgi Lab and collaborators just published in eLife! "R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling" doi.org/10.7554/eLife.…

Congratulations Maia!

Woohooo!!! 🥳🎉 Our paper just went online Developmental Cell! The major fundamental question we sought to address was, what are the mechanisms that regulate a receiving cell’s sensitivity to extracellular morphogens? 🧵🧵🧵 cell.com/developmental-…

Rohatgi Lab, Arun Radhakrishnan, & Christian Siebold review how the Hedgehog (Hh) receptor PTCH1 uses its transporter-like function to inhibit the GPCR SMO, with cholesterol as a ligand for SMO to effect downstream signaling. go.nature.com/2HduKgI

New preprint on the mechanism of action (MOA) by which oxaliplatin kills cells, from the Rohatgi Lab and Onn_Brandman lab, both Stanford Biochemistry! biorxiv.org/content/10.110…

Congrats Jennifer Kong, PhD, glad to see this out: biorxiv.org/content/10.110…. Cool idea to tune development signaling in utero to manage birth defects.

Yay! Our pre-print is finally out on BioRxiv! I am thrilled to finally share chapter 3 of our MMM saga: the mystery of MOSMO! Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength biorxiv.org/content/10.110…

Huge congratulations to ⁦Lauren Schmidt — a 2021 Forbeck Fellow⁩!!!! 🎉🎉🎉🎉🎉🎉 wgfrf.org

Check out this new pre-print from Pawel Niewiadomski's lab!