The Calcium Sensing Receptor (CaSR) is known to couple to multiple G-proteins. Here is the structural basis how: nature.com/articles/s4158…

Membrane tension is hard to measure, as you need to know the radius of the membrane to calculate it from the applied pressure (Laplace’s law). This paper uses patch clamp and imaging to quantify membrane tension dependence of TRAAK and TREK K+ channels. nature.com/articles/s4146…

Solar eclipse with and without clouds.

TMC1 and TMC2 are the pore forming subunits of the mechanically activated channel responsible for hearing. What the other members of this family do is less clear. New paper shows that TMC7 is a suppressor of Piezo2 channels in primary sensory neurons. cell.com/cell-reports/f…

Very cool study that exploits our optogenetic membrane editors to help discover a role for the anionic lipid phosphatidic acid in attenuating the PIEZO2 mechanosensitive channel #lipidtime

Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity biorxiv.org/cgi/content/sh… #biorxiv_neursci

Check out our latest work by Matthew Gabrielle on BioRxiv, where we identified endogenous lipid modulators that selectively inhibit Piezo2 channels over Piezo1 and modulate mechanosensitivity in mice. biorxiv.org/content/10.110…

Check out our results about 'Molecular details of ruthenium red pore block in TRPV channels' and the intimate relationship between channel gating and pore blocking.
embopress.org/doi/full/10.10…

Thanks for the great collaboration !

From the New York Times: worth reading it: nytimes.com/2024/01/07/bri…

The New York times has just published a story supporting standardized testing.

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Using cryo-EM, electrophysiology, and MD simulation, we determined that the binding site of econazole in TRPV5, akin to TRPV6, is constituted by L475, F472, and W495, participating in CH−π interactions.
authors.elsevier.com/a/1iIb23SNvc6o…

The application portal to our PhD program is open. Apply if you are interested in Neuroscience, Cardiovascular Biology, Stem Cell biology and more. Deadline to be considered for an in-person interview is January 5, but apply ASAP, as slots fill up. njms.rutgers.edu/sgs/prospectiv…

Interested to know more about PhD programs at Rutgers Biomedical and Health Sciences? Please join us next Monday for a virtual Q and A! Register here: njms.rutgers.edu/sgs/#meet #science #phdlife #gradschool

Are you interested in applying to PhD programs ? Visit our Booth (#52) at #SfN23 open 12 noon - 2 PM till Tuesday. Or visit our website: njms.rutgers.edu/sgs/prospectiv…