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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

If you are new to the field of artificial metalloenzymes or simply want to know where things stand, check out our new primer on the topic Nature Reviews Methods Primers nature.com/articles/s4358…

Boron Designer Enzyme with a Hybrid Catalytic Dyad (Roelfes Group (find us as @roelfesgroup on BS)): pubs.acs.org/doi/10.1021/ac… (ACS Catalysis).

🥳🥳🥳 Early Christmas Present for Francesca Grisoni Robert Pollice and me! NWO Funding awarded us €2.7 million for our NWO-XL grant "ML-GUIDE – Machine Learning-GUIded Directed Evolution for drug discovery and (bio)catalyst engineering"! Best! Consortium! Ever! nwo.nl/en/news/64-mil…

Artificial Gold Enzymes Using a Genetically Encoded Thiophenol-Based Noble-Metal-Binding Ligand (Gerard Roelfes and co-workers) Roelfes Group (find us as @roelfesgroup on BS) #openaccess 🔓 onlinelibrary.wiley.com/doi/10.1002/an…

Season's greetings from Roelfes and Mayer narf42 groups! Wishing our colleagues, collaborators, and the entire community a joyful holiday season and a prosperous New Year ahead! 🎉🎄✨🧪

Fantastic start of 2025 for the group. Our own Lars Longwitz won the University of Groningen FSE Postdoc prize for 2024. This prize celebrates his excellence in research and great potential of becoming a scientific leader. Well well deserved Lars! 👏 @StratinghInst

A good start to the new year: I was awarded the Postdoc Prize 2024 of the Faculty of Science and Engineering in Groningen! Very happy to receive this award to recognize my achievements in the Roelfes Group (find us as @roelfesgroup on BS) ! Now, I am looking for a new adventure!

Check out our latest work where we combined mutagenesis, crystallography, and computational approaches to uncover the evolutionary specialization of a promiscuous designer enzyme. Kudos to Reuben B. Leveson-Gower and the entire team! Find more details in the thread below:

Delighted to announce that 'Engineered enzymes for enantioselective nucleophilic aromatic substitutions' is out now in Nature! Congratulations to Tom, George and everyone else involved in this project! 🎉🎉🎉 nature.com/articles/s4158…

Exciting PhD opportunities coming soon in the EVOLVE consortium! 🚀 Focus: origins of molecular chirality & prebiotic chemistry. 🧪 Seeking motivated students in organic synthesis, stereochemistry, or supramolecular chemistry. 🌟 evolve-programme.eu/the-origin-of-… evolve-programme.eu/expanding-preb…

📢📢📢The ML-GUIDE team (Francesca Grisoni, Robert Pollice and myself) are looking for 3 PhD students, passionate about combining the directed evolution of diverse biomolecules with deep learning approaches to develop better (bio)catalysts and drugs! Pls retweet tinyurl.com/3jz97ter