Robert Dick Lab
@robdicklab
Investigating the mechanisms of retrovirus budding and maturation using a combination of biochemistry, cell biology, and cryo-EM starting at @EmoryMedicine soon
ID: 1024443200407257089
http://blogs.cornell.edu/robdicklab/ 31-07-2018 23:54:26
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Research Cornell CALS provides details of how the structure of the HIV-1 virus is assembled, offering potential new targets for treatment. news.cornell.edu/stories/2018/0…
Our work on Rous sarcoma virus is now online Nature Communications. A continuation of the IP6 story with RSV structures! It was a joy to work with everyone. Special thanks to Florian Schur and Martin Obr @SchurLab. nature.com/articles/s4146…
Thanks Alister Burt for the starfile tool! Had fun using it to play with some Relion 4 data!
Inositol Phosphates and Retroviral Assembly: A Cellular Perspective mdpi.com/1405604 #mdpiviruses via Viruses MDPI
Our very first print with our Flashforge® Guider IIs - Iron Throne Benchy! Next, we'll test the integrity of different filaments at cryogenic temperatures #3DBenchy
What is more fun than studying viral assembly, release and maturation here Robert Dick Lab Cornell University doi:10.1038/nrmicro3490
EMPIAR.org/EMPIAR-11575 is the raw data of the "Defective HIV-1 capsid lattice assembled on 30-nm liposome scaffolds in the absence of assembly cofactor IP6". Published PNASNews (doi.org/0.1073/pnas.22…) by the John Briggs and Robert Dick Lab Max Planck Institute of Biochemistry (MPIB) and Cornell University. #EMPIAR
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from Margot Riggi :