Chick embryos showed wry neck and other muscular problemsand had cardiac malformations and thoracogastroschisis.

Demeton toxicity in avian embryos is due to abnormal muscle function associated with cholinesterase inhibition.

Demeton is an organophosphate pesticide marketed as Systox.

Fish oils (#2249) contain the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

We just added pertuzuman (Perjeta) to Reprotox.

This monoclonal antibody that antagonizes the HER2/neu receptor by preventing its dimerization with other receptors.

Pertuzumab given intravenously to pregnant cynomolgus monkeys every 3-4 days, caused abortion and decreased fetal weight

Pertuzumab is marked for the treatment of breast cancer in combination with trastuzumab and docetaxel.

Pertuzumab also caused oligohydramnios and fetal renal lesions in monkeys.

Pertuzumab is not recommended for nursing women according to the product labeling, in spite of a lack of data.

Pertuzumab is not recommended during pregnancy based on its prominant fetal toxicity in monkeys.

It is not clear the pertuzumab, which is a monoclonal antibody, would be absorbed by a nursing infant.

Omega-3 fatty acids havwe a double bond at the 3rd carbon when counted back from the last methyl group.

A diet rich in fish (and, perhaps, the corresponding lifestyle may reduce the incidence of cardiovascular disease.

A 2012 study reported associations between omega 6:3 ratio and infant brain development.

There are no reports on the possible reproductive toxicity from the use of omega-3 supplements during human pregnancy.

Omega-6 fatty acids are more commonly consumed, and typical ratios in the US are 10 or 20 to 1.

Elevated dietary DHA or fish oil + omega-6 supplements did not significantly increase congenital defects in rats.

Other studies on the use of fish oil omega-3 supplements in pregnancy did not find significant beneficial effects.

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