5Y evaluation of for our CD-Lab MedUni Wien & Boehringer Ingelheim for #PortalHypertension & #LiverFibrosis. 🗝️achievements: - investigation of #sGC signaling in liver disease - established #fibrosis #regression models - prognostic #biomarker - #scRNAseq in #PSC

❓Best Trial Design in #MASLD #MASH #Cirrhosis 🎯Adapted Endpoints according to Target Population 🧑‍⚖️U.S. FDA 💊#EMA Guidance 🩸#Varices as #OrdinalOutcomes Nature Reviews Gastroenterology & Hepatology 📕t.ly/HMhe0

#LiverTwitter World Health Organization (WHO) #ViralHepatitis #Elimination NOT on track ‼️ >2 Mio new cases /y 2022 ‼️ 300 Mio people affected ‼️ 1.3 Mio death /y #HepB 🔍only 13% diagnosed 💊only 7% treated 💉only 18% HBV newborn vaccination in Africa #HepC 🔍 36% diagnosed 💊 20% treated/cured

#livertwitter #MASLD #MASH #BariatricSurgery A prospective study by Lukas Hartl, Georg Semmler & Nina Dominik performed MedUni Wien demonstrates: rapid improvement of hepatic #steatosis and liver stiffness #LSM after metabolic/bariatric surgery pubmed.ncbi.nlm.nih.gov/39080285/

#Livertwitter The Baveno Cooperation: an EASL Consortium study !! #PortalHypertension severity #HVPG predicts hepatic decompensation in patients with compensated #MASLD #MASH cirrhosis 📕Journal of Hepatology sciencedirect.com/science/articl…

❗️Primary Bleeding Prophylaxis in pts with cirrhosis Child-B/C and high-risk #varices ✅Carvedilol reduces #portalpressure 😯combination with ligation #EVL : most effective to prevent first bleeding & mortality Gut Journal 📕t.ly/Xj0gw #livertwitter

This will likely be the status of cirrhosis by 2050: 📈Number of deaths increased by 50% 🔟th leading cause of death 🤏Small (-9%) decrease in age-adjusted death rate, much less than top 3 doi.org/10.1016/S0140-… #LiverTwitter #globalburdenofdisease

🇦🇹#CDLab for #PortalHypertension & #LiverFibrosis MedUni Wien co-supported by Boehringer Ingelheim 🌐t.ly/mVrN4 3⃣achievements 👁️sGC stimulation improves #PortalHypertension 🕸️fibrosis is distinct for #liverdisease etiology 🔥systemic inflammation increases with cirrhosis

#livertwitter 840 pts with liver disease undergoing same-day #LiverStiffessMeasurement #LSM by 2D-Shearwave-Elastography #ElastQ (Philips) and #Fibroscan (Echosens) ✅ IQR/med <30% indicates reliable #ElastQ-LSM 📕t.ly/7D1M3

🚨Job Alert🚨Looking for an excellent Postdoc to join our team (Abdel Fattah Lab) at CeMM Austrian Academy of Sciences in Vienna! A fantastic collaborative dynamic environment where we will use bioengineered tools to investigate multiscale mechanobiology. Please RT. Link 👇 nature.com/naturecareers/…

Globul Burden of Disease #WHO 🔑points: 🇦🇹 2022 Born Life Expectancy: F 84.7 vs M 80.3 years 🌎leading causes of death: #Cirrhosis from 11th (2022) to 10th place in 2025 🫢DALY counts increase for non-communicable diseases in high-income countries ➡️ concerted action plans !

🏥 Highest burden of #LiverDisease is concentrated in the #Asia #Pacific Region ‼️ where 1/2 #cirrhosis 💀deaths and 3/4 of #LiverCancer #HCC deaths occur! Nature Reviews Gastroenterology & Hepatology 🆘Measures: - HBV vaccine - HCV DAA therapy - Alcohol policies - Betablockers for #PortalHypertension

Screening cascade for hepatitis D in France ✅screen once in people with hep b ✅follow through with necessary testing (if antibody positive, look for virus) A long way to go given this current state Authors argue for reflex pcr testing doi.org/10.1111/liv.16…

New research from katherlab on #computational #pathology: We benchmark pathology foundation models 👇 Several of these are publicly available under permissive licenses. arxiv.org/abs/2408.15823 Some takeaways: 1. The vision-language model CONCH (Faisal Mahmood) outperforms

How much 🍻Alcohol is in #MASLD? important to know sind it does make difference! 📕t.ly/RdHD- but #PortalHypertension remains a key driver of #liver #Events 📕t.ly/GUx2Q Reply 📨 t.ly/BQetE by @wilcokwanten Benedikt Hofer Sven Francque

A how to for multidisciplinary clinics in hepatology doi.org/10.1097/hep.00… in HEPATOLOGY Journal Anjana Pillai

While self-reported #Alcohol consumption performs ok - at least wtihin clinical trials #PEth seems to be the most reliable alcohol #biomarker - in regard to prediction of #liver-related events #decompensation The Baveno Cooperation: an EASL Consortium EASLnews Congrats Mads Israelsen in JHEP Reports

#LiverTwitter #LiverDisease ♀️♂️ sex disparity & sex/hormone differences in hepatic immune regulation infuence & modify the development of #autoimmune and #genetic liver diseases, #PortalHypertension & 🔥#Infammation‼️ Nature Reviews Gastroenterology & Hepatology 📕t.ly/X33H9