Our Board members Andi Pollinger and Lara Metcalf had a great time at the MassChallenge Showcase. Reboot Rx was in the MassChallenge Accelerator in 2019, where we met Andi, one of our mentors and now our Board Chair. We love supporting #Boston #startups !

#MCResolve24

In case you missed it, our Founder and CEO Laura Kleiman recently published an Op-Ed in the The Boston Globe about the market failure for generic #drugrepurposing . The article is now available on our blog: rebootrx.org/blog/boston-gl…. #cancer

We are proud to share this case study by Amazon Web Services and The Chronicle of Philanthropy featuring our work at Reboot Rx. Check it out! 👉drive.google.com/file/d/1W-b5qs…

#RebootRx #TheSolutionMayAlreadyExist #cancer #drugrepurposing #AI #patientimpact #research

#MeetTheTeam - Meet Sierra Silverwood, our new Biomedical Scientist Intern at Reboot Rx! Sierra is a medical student at Michigan State College of Human Medicine and has experience with healthcare management, clinical research, pharmaceutical R&D, and implementation science.

The R&D ecosystem has driven major advances in cancer, but there are important areas of research that could help patients and reduce healthcare costs, but aren't being done because of misaligned incentives... bostonglobe.com/2023/12/27/opi…

Happy New Year! We are on the cusp of changing how we treat early-stage prostate #cancer with our first generic drug and scaling our innovative approach for other cancers. We’re excited about what 2024 has in store for us and the patients who will benefit from these treatments.

In my The Boston Globe Op-Ed today, I urge the US government and philanthropists to ensure that Americans can benefit from repurposed generic drugs: bostonglobe.com/2023/12/27/opi….

Reboot Rx #RebootRx #TheSolutionMayAlreadyExist #cancer #drugrepurposing #nonprofit

Three of our team members found themselves in New York City at the same time and had the opportunity to meet up. As a remote organization, we always treasure our in-person time together. They wish everyone #HappyHolidays on behalf of the whole Reboot Rx team!

Yesterday was a special day as I returned to Dana-Farber to give a talk on our work at Reboot Rx. It was great to reconnect with past colleagues and wonderful to see Pradeep Mangalath at the place where our journey building Reboot Rx began. #cancer #research #nonprofit

We imagine a world where everyone has access to affordable #cancer treatments. This #GivingTuesday , we want to extend our heartfelt thanks to the incredible people who make our mission possible. You can help us reach our next milestones with a donation at rebootrx.org/donate.

I enjoyed speaking at the #ACSBrightEdgeSummit on a panel moderated by Bill Dahut, MD from American Cancer Society. Too many patients struggle to access #cancer treatments. Reboot Rx is working to mitigate #financialtoxicity and #healthinequities through generic #drugrepurposing .

Ketoconazole was repurposed for #prostatecancer after men treated for fungal infections experienced breast tissue enlargement. Understanding its mechanism of action later inspired the development of abiraterone, a new drug with a more favorable toxicity profile. #drugrepurposing

Thalidomide was once used to treat pregnancy-related morning sickness but was recalled due to causing birth defects. It made a groundbreaking comeback when it was repurposed for treating #multiplemyeloma as an immunomodulatory drug. #drugrepurposing Multiple Myeloma RF

The BCG vaccine for tuberculosis was repurposed for #bladdercancer following a serendipitous clinical observation. BCG reduces the risk of recurrence and progression in high-risk non-muscle invasive bladder cancer and was the first cancer #immunotherapy to be FDA-approved.

Acute promyelocytic leukemia (APL) is an aggressive and historically fatal subtype of acute myeloid leukemia (AML). ATRA, previously FDA-approved for acne, was later repurposed as a treatment for #APL . APL is now considered the most curable type of AML in adults. #drugrepurposing

We are often asked for examples of successful #drugrepurposing . Over the next few weeks, we will spotlight a few non-cancer drugs that have been repurposed as effective #cancer therapies. You may be surprised to learn how these familiar drugs have taken on new, life-saving roles.

One of our top drug candidates for #prostatecancer is a very cheap generic. If it becomes the standard of care, it could prevent or delay prostate cancer progression for 70K patients each year and save $3B in the U.S. alone. #ProstateCancerAwarenessMonth

Our AI tech found over 80 generic drugs tested for treating #prostatecancer . Through rigorous manual validation, we whittled it down to the drugs with the strongest evidence and are now determining a pathway to advance them into the standard of care. #ProstateCancerAwarenessMonth

For our #prostatecancer project, we used our #AI tech to analyze data from 16K published studies and rank non-cancer generic drugs based on the totality of evidence. We found 80+ generics tested in at least one clinical study for prostate cancer. #ProstateCancerAwarenessMonth

For #ProstateCancer AwarenessMonth , we are sharing why we chose to work on #ProstateCancer and our progress. It is a common cancer, many non-cancer generics have already been tested for prostate cancer, and oncologists and patients were eager to collaborate.