Amazing dinner at #ECCO2023 with these 🇦🇺 + 🇩🇰 powerhouses of IBD 🤰 Sally Bell Mette Julsgaard

More confirmation of UST/VDZ safety in pregnancy. Infant levels mostly gone by 15 weeks. ⁦UST levels stable, VDZ levels drop but disease activity stable. nice work by ⁦Emily Wright⁩

First human data on high conc. of #JAKinhibitors in breast milk: #tofacitinib is contraindicated during lactation. The Lancet Gastroenterology & Hepatology Great collaboration between IBD Leuven Uma Mahadevan Department of Hepatology and Gastroenterology, AUH Aarhus Uni.hospital PREDICT IBD Aarhus University

Amazing work by the PICCOLO team for their work in IBD and pregnancy. Thiopurines associated with increased risk of ICP in IDB pregnancies. Ralley Prentice Sally Bell

78 #IBD pregnancies. 👶🏼ustekinumab clearance = 6 months ➡️ live 💉from 6 months of life is low risk. ⬇️risk of 👶🏼infections and normal development at 12 months.🇩🇰🇳🇱OPEN ACCESS cghjournal.org/article/S1542-… Gastroenterology CGH Department of Hepatology and Gastroenterology, AUH Crohn & Colitis - Erasmus MC Aarhus Uni.hospital HealthAU PREDICT IBD

Happy to share our case. We hope this adds to the discussion with pts of childbearing age who are candidates for JAKi with no other options than surgery. academic.oup.com/crohnscolitis3… Cynthia Seow Remo Panaccione, MD, FRCPC Kerri IBD YYC

The U.S. FDA has issued a safety alert warning patients and health care providers of a “rare risk of #intrahepaticcholestasis of pregnancy🤰🏽” linked to #thiopurine 💊 use. ⬇️⬇️ healio.com/news/gastroent…

#SundayRead☕️ #Thiopurines & #IBD #Pregnancy ⚠️AZA shunting in 24% of🤰🏼 ⚠️⬆️MMP/6TG ratio in 3rd trimester->⬆️ Risk of intrahepatic cholestasis of pregnancy #ICP 💎What can be done ✔️Split Dose in 2nd trimester 🚫Don’t⬆️Dose pre🤰🏻 🔎Monitor levels in🤰🏾 ✋🏽Stop AZA if not needed?

Really proud of the amazing PICCOLO ⭐️’s Sally Bell Emma Flanagan who are contributing to this impactful and innovative worldwide consensus for IBD pregnancy care 💪

Really cool pilot study from Mette Julsgaard et al on the use of 2nd trimester placental MRI for predicting small for gestational age 👶🏻 in chronic inflammatory disorder 🤰. Steps towards refining how we can risk stratify care for our IBD 🤰 link.springer.com/article/10.100…

Choy - Intensified (10 mg/kg) and accelerated (5 mg @ shorter intervals) not superior to standard IFX dose for induction of response in ASUC #colitis patients w moderate-severe endoscopic activity. More is not better X when Albumin is low #DDW2024 #IBD Very important study

Hot of the press: Upadacitinib safety in pregnancy. 128 maternal pregnacies all exposed in the first trimester primarily. MotherToBaby Mette Julsgaard Millie Long link.springer.com/article/10.100…

Remember✅metabolites, lft in🤰 on thiopurine due to (small)⬆️ risk ICP. U.S. FDA warning. Thanks Ralley Prentice Emma Flanagan S.Bell for bringing this to our attention. doi.org/10.1093/ecco-j…

Risankizumab, IgG1, has lower than expected placental transfer rates with infant > mom. Millie Long PIANO UCSF Health Low Placental Transfer Rates of Risankizumab Among Pregnant Women With Inflammatory Bowel Disease academic.oup.com/ibdjournal/art…