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The Oscar is gone. We are nominating for the Worst Figure Awards 2026 I just voted for Professor Mervin Singer, on his Lancet Seminar on sepsis. Prompt: please turn this list into a figure 😂 thelancet.com/journals/lance… The Lancet Lawrence Lynn Ash Paul Todd C. Lee NonsparseOncologist

The SOHO study (HFNO vs. standard oxygen) is out today, and on its way to The Land of Irrelevance. open.substack.com/pub/thethought… Lawrence Lynn IMCrit 𝙟𝙤𝙨𝙝 𝙛𝙖𝙧𝙠𝙖𝙨 💊 Ash Paul Segun Olusanya (He/Him) [email protected] Ken Milne MD Critical Care Time ERS Todd C. Lee Philippe Rola ISICEM Wojciech Rojewski

(…) Of course, more alveolar oxygen would, to some extent, guarantee more oxygen in the blood. This is a first-order effect. No placebo-controlled randomized clinical trial is needed to determine a first-order effect. Morphine mitigates pain. It just happens in front of you.

(...) That’s enough for an outright dismissal of mortality reduction in the SOHO study. Of course, all patients were intubated and ventilated when necessary to prevent death. The dominant cause of death was addressed by mechanical ventilation in both groups. Hence, by missing the

Personality cult and networking. Academic critical care in a nutshell. Lawrence Lynn

Rafael Olivé Leite Ash Paul Mentees seeking real discovery would be better served asking their mentors about the actual history of critical care’s synthetic syndrome science, outlined below, rather than networking within the system that institutionalized it. #SCCM2026 link.springer.com/article/10.118…

TIGRIS trial inaugurates a new era in critical care research. The age of Bayesian Circular Reasoning How to do it: 1) Torture an old dataset. Dichotomize data, create arbitrary subgroups, do what is necessary for the dataset spits a subset of patients that benefits from your

Tomorrow in The Thoughtful Intensivist thethoughtfulintensivist.substack.com #Bayes