If you ever wanted to *really* know what is happening to PBMC in healthy aging - now you know! Just out in Immunity , our latest work in immune aging - dissection of >300 PBMC samples aged from 25 to 85 years. Huge dataset and detailed annotations. sciencedirect.com/science/articl…

Fantastic to share new work led by Sarah Whiteside published today in Science Immunology. We find that CD4+ conventional T cells acquire suppressive functions upon Treg depletion limiting efficacy of Treg-targeted therapies. Collaboration with Lugli Lab🧵👇 science.org/doi/10.1126/sc…

There are now several approaches to achieve targeted degradation of extracellular and membrane proteins, including sweeping antibodies, LYTACs, ATACs, AbTACs, PROTABs and KineTACs - read all about them in this recent review bit.ly/489BXVZ rdcu.be/dtT1P

We are very excited to present the development of Zman-seq (“Zman”, Hebrew for “time”), the 1st technology that measures single-cell transcriptomes and physical time in vivo, led by Daniel Kirschenbaum, Ken Xie, Florian Ingelfinger, Assaf Weiner sciencedirect.com/science/articl…. (1/19)

Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism dlvr.it/T0ySTw

We have shown with Roychoudhuri Lab that CCR8+CD4+ Tconv make IL-10 and mediate resistance to Treg depletion in solid tumors. Now Li Tang shows that IL-10 expressing CAR T resist exhaustion! Incredible biology of IL-10 🤯

#Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis ⁦Nature Cell Biology⁩ nature.com/articles/s4155…

Online Now: Interferon-stimulated neutrophils as a predictor of immunotherapy response dlvr.it/T10XST

An oncolytic virus–T cell chimera for cancer immunotherapy go.nature.com/48aEcIe

Two groups recently showed that circulating CD8+ T cells specific for MCPyV oncoproteins at baseline could be used to predict clinical outcomes for response and survival in patients with Merkel cell carcinoma 👉 bit.ly/3UBCPPD  University of Washington  Paul Nghiem  Fred Hutch Cancer Center  Evan Newell

IL-23 sensing represents a crucial signal driving the maintenance and stabilization of effector Treg cells (via Foxp3) in the tumor microenvironment @BecherLab Nature Immunology Tobias Wertheimer Pascale Zwicky nature.com/articles/s4159…

Cancer-targeting antibody–drug conjugates drive dealmaking frenzy go.nature.com/3IgwQII

A new method (uLIPSTIC) can decipher cell–cell interactions on a large scale nature Victora Lab is at Bluesky Yuri Pritykin sandra nakandakari higa nature.com/articles/d4158…

A paper in nature reports insights into the genetic basis of tail loss during the evolution of humans and apes (hominoids). The authors propose that tail-loss evolution may have led to an increased likelihood of neural tube defects in humans and apes. go.nature.com/4bR8Klh

IL-1β signals reversibly affect naive T cell phenotypes, with enriched neutrophil derived IL-1β in spleen reducing the differentiation regulatory T cells Cell Reports cell.com/cell-reports/f…

Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity Nature Immunology nature.com/articles/s4159…

So excited to have this paper out now! Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. cell.com/cell/abstract/… @uconnresearch UConn Health 1/3

Absolutely an amazing idea!

Study of biologists quitting academia reveals hidden gender gaps nature.com/articles/d4158…

BACH2 regulates T cell lineage states to overcome dysfunction driven by tonic CAR signaling researchsquare.com/article/rs-584… Nathan Singh