We are looking for a couple of Research Technicians to join us in the Fischer Lab! If you enjoy biochemistry/chem bio and are interested in working in a great team exploring degrader induced interactions and degradation reach out or apply:
careers.dana-farber.org/job/research-t…

Please RT!

Check out our game, DEGRADATOR! 🎮 Designed to popularize and educate on the ubiquitin-proteasome system and PROTACs. Perfect for kids 12+ but not only 😉 Dive into 10 fun levels to explore protein degradation. Available on Google Play and degradator-game.com 🚀

Gaining insight into the molecular control of PP2A activity is crucial for the development of allosteric phosphatase activation as a novel therapeutic approach for hard-to-treat pedi cancers. Amazing Radek Nowak Fischer Lab Dana-Farber Chemical Biology Program Harvard Med BCMP
jbc.org/article/S0021-…

#AlphaFold can accurately predict PP2A complexes! We solve the structure of #PP2A A R5E C complex and show that PP2A phosphatase assembly is independent of the C subunit methylation. Great team with amazing Franziska Wachter Fischer Lab #Xray
jbc.org/article/S0021-…

Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF disq.us/t/4nmwglh
🤝 Proud to collaborate with Sandi Radko-Juettner on this groundbreaking research. Together, we're advancing cancer therapeutics and structural biology. Stay tuned for more updates!

Just in time for #HumpDay : Our study Targeting DCAF5 suppresses #SMARCB1 -mutant #cancer via stabilizing SWI/SNF is online now in nature. Congratulations 🎉 to co-first authors Sandi-Radko-Juettner and Hong Yue and all co-authors on this story! 1/
nature.com/articles/s4158…

April 4th at 11am EDT, Brian Liau (Brian Liau) from Harvard Chemistry will present in our DFCI TPD seminar series, sharing a new degrader mechanism entitled 'Chemical Facsimile of E3 Cancer Mutations Promotes Corepressor Degradation'. Very much looking forward to this seminar!

Fantastic talks by Prof Lyn Jones and Prof Alessio Ciulli at the Neuroblastoma UK 🎗 Research Symposium, about the potential of targeted protein degradation against cancers including neuroblastoma. Thrilled to see these leaders championing their work in children’s cancers!🎗️

Congratulations Hubert and team! Such an elegant method for identification of ubiquitinated substrates! #ESTUB #ubiquitination #E3ligases Hubert Huang Katherine A Donovan Yuan Xiong Nada Mageed Fischer Lab

Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ nature.com/articles/s4158… rdcu.be/dBUju

Dear network,
I am looking for a PhD student to study nutrient absorption and its regulation in the gut using organoids to join our lab. Looking forward to applications from highly motivated candidates. Please share.

Degradation meets directed evolution! Congratulations Fischer Lab David R. Liu teams! #degrontag #SD40

We engineered a new tool to interrogate biological pathways and validate cancer dependencies! This new degron can be fused to your protein of interest at its genomic locus to degrade it within an hour using a clean compound. science.org/doi/10.1126/sc…
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Congratulations Fischer Lab team - it was fantastic to see it in making! And what a structure! #CRBN #cryoEM Shourya S Roy Burman Moritz Hunkeler

Great to see this story out - congrats to the team 🎉

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome

Highly recommend! Amazing chance to work on cutting edge Chemical Biology in Boston. #chembio #covalent

We are looking for a postdoctoral research fellow to work with Eric Fischer and myself to pioneer next-generation covalent drug discovery. Please retweet. Apply here: careers.dana-farber.org/jobs/?search_t… Fischer Lab

Another exciting double talk webinar session next week! Join us to hear Shourya S Roy Burman & Stephan talk about their soon-to-be published work evolving small protein degradation tags for targeting by CRBN MG's and Georg Petzold will tell us about how he has been teaching CRBN new tricks!

Are you interested in strategies to control the spatial localization of your favorite protein at will? In our review, Saurav Kumar and I discuss the exciting development of chemical inducers of proximity to control subcellular protein localization. authors.elsevier.com/a/1ikNC3S7Zk9Z…